Sugi Predict

Sugi Predict / Compounds / SCHEMBL5879280

SCHEMBL5879280

SCHEMBL5879280

O=C1C=C(c2c[nH]c3cccc(Br)c23)C(=O)N1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP2A6 P11509 1/20 0.45
▸ CLK1 P49759 5/20 0.43
▸ CDK5 Q00535 4/20 0.43
▸ CDK5R1 Q15078 4/20 0.43
▸ FGFR1 P11362 2/20 0.43
▸ FGFR2 P21802 2/20 0.43
▸ FGFR3 P22607 2/20 0.43
▸ PARP1 P09874 2/20 0.37
▸ CAMK2D Q13557 4/20 0.36
▸ CCNE2 O96020 3/20 0.36
▸ CDK4 P11802 3/20 0.36
▸ CCND1 P24385 3/20 0.36
▸ CCNE1 P24864 3/20 0.36
▸ CDK2 P24941 3/20 0.36
▸ CCNB2 O95067 2/20 0.36
▸ CDK1 P06493 2/20 0.36
▸ CCNB1 P14635 2/20 0.36
▸ PRKACA P17612 2/20 0.36
▸ PRKACG P22612 2/20 0.36
▸ PRKACB P22694 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5879234 0.82 GPR84 (0.44) PARP1CAMK2DCCNE2CDK4CCND1
SCHEMBL5879293 0.82 HTR2B (0.43) CDK5CDK5R1PARP1CAMK2DCCNE2
SCHEMBL5879188 0.82 FFAR1 (0.44) PARP1CAMK2DCCNE2CDK4CCND1
SCHEMBL5879276 0.82 GPR84 (0.44) PARP1CAMK2DCCNE2CDK4CCND1
SCHEMBL5879162 0.82 CLK1 (0.45) CLK1CDK5CDK5R1FGFR1FGFR2
SCHEMBL5879149 0.79 HTR2A (0.47) CDK4CCND1CDK2ABL1PRKCB
SCHEMBL5879296 0.78 CLK1 (0.49) CLK1PARP1CAMK2DCCNE2CDK4
SCHEMBL6046967 0.77 GSK3B (0.41) CDK5PIM1
SCHEMBL5879217 0.77 CLK1 (0.43) CLK1CDK5CDK5R1PARP1CAMK2D
SCHEMBL2193383 0.75 PRKCB (0.65) CAMK2DCCNE2CDK4CCND1CCNE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110218206-B Bisindolylmaleimide derivative and preparation method and application thereof 中国海洋大学 2022-03-04 — — CN disclosed
CN-110526903-B Bisindolylmaleimide derivative and preparation method and application thereof 中国海洋大学 2021-12-10 — — CN disclosed
US-7151108-B2 Anticarcinogenic, antiproliferative, and antitumor agents LES LABORATORIES SERVIER (FR) 2006-12-19 — — US disclosed
EP-1411057-B1 [3,4-a:3,4-c]carbazole derivatives, process for their preparation and pharmaceutical compositions containing them SERVIER LAB (FR) 2005-04-27 — — EP disclosed
US-20040077672-A1 Anticarcinogenic, antiproliferative, and antitumor agents LES LABORATOIRES SERVIER (FR) 2004-04-22 — — US disclosed
EP-1411057-A1 [3,4-a:3,4-c]carbazole derivatives, process for their preparation and pharmaceutical compositions containing them Les Laboratoires Servier (FR) 2004-04-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040077672-A1 Anticarcinogenic, antiproliferative, and antitumor agents XDH, TOP2A, TOP1 CYP2A6 633/4885CLK1 4556/4885CDK5 3798/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.