SCHEMBL6046967

SCHEMBL6046967

O=C1C=C(c2ccccc2Br)C(=O)N1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.41
IDO1 P14902 2/20 0.39
TDO2 P48775 1/20 0.39
ALDH1A1 P00352 2/20 0.39
MAPK1 P28482 2/20 0.39
LRRK2 Q5S007 2/20 0.38
DYRK1B Q9Y463 2/20 0.38
PIM1 P11309 1/20 0.38
CSNK1A1 P48729 1/20 0.38
CDK5 Q00535 1/20 0.38
ROCK1 Q13464 1/20 0.38
DYRK1A Q13627 1/20 0.38
CLK4 Q9HAZ1 1/20 0.38
CASP3 P42574 1/20 0.36
CASP2 P42575 1/20 0.36
CASP7 P55210 1/20 0.36
CASP6 P55212 1/20 0.36
CASP8 Q14790 1/20 0.36
PARP10 Q53GL7 1/20 0.36
PARP11 Q9NR21 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL121405 0.86 GSK3B (0.50) GSK3BIDO1ALDH1A1MAPK1LRRK2
SCHEMBL27664385 0.86 GSK3B (0.50) GSK3BIDO1ALDH1A1MAPK1LRRK2
SCHEMBL6046984 0.85 PIM1 (0.40) GSK3BIDO1TDO2LRRK2DYRK1B
Ammonia Solution, Strong SCHEMBL27972740 0.84 PIM1 (0.39) GSK3BIDO1TDO2LRRK2DYRK1B
SCHEMBL11120799 0.84 GSK3B (0.48) GSK3BIDO1ALDH1A1MAPK1LRRK2
SCHEMBL10591930 0.78 TGM2 (0.44) LRRK2PARP10PARP11KMT2AMEN1
SCHEMBL15051612 0.78 TDP2 (0.45) PARP10PARP11MAOAMAOBPTPRC
SCHEMBL1050913 0.78 GSK3B (0.41) GSK3BLRRK2DYRK1BPIM1CDK5
SCHEMBL5879217 0.77 CLK1 (0.43) GSK3BPIM1CDK5DYRK1A
SCHEMBL5879280 0.77 CYP2A6 (0.45) PIM1CDK5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110724154-A Polysubstituted pyrrolo [3,4-d ] isoxazole derivative and synthetic method thereof 湖北科技学院 2020-01-24 CN claimed
CN-110418783-A Process for purifying N-substituted maleimides LG CHEMICAL LTD 2019-11-05 CN claimed
CN-110198927-A Process for purifying N-substituted maleimides 株式会社LG化学 2019-09-03 CN claimed
CN-100558776-C A kind of preparation method of polymer modified styrene resin for energy saving JIANGSU SHENGJIE INDUSTRY CO L (CN) 2009-11-11 CN claimed
JP-4372613-A None JP disclosed
CN-118599234-A Styrene resin composition, flame-retardant styrene resin composition, molded article, and patch antenna PS日本株式会社 2024-09-06 CN disclosed
CN-115087702-B Styrene resin composition, flame-retardant styrene resin composition, molded article, and patch antenna PS日本株式会社 2024-05-31 CN disclosed
US-20230099634-A1 STYRENE-BASED RESIN COMPOSITION, FLAME RETARDANT STYRENE-BASED RESIN COMPOSITION, MOLDED BODY, AND PATCH ANTENNA PS JAPAN CORPORATION (JP) 2023-03-30 US disclosed
EP-2765145-B1 SILYLATED POLYBUTADIENE NIPPON SODA CO (JP) 2022-03-02 EP disclosed
EP-3864093-A1 WATER DISPERSIBLE SULFONATED THERMOPLASTIC COPOLYMER FOR USE IN ADDITIVE MANUFACTURING Stratasys, Inc. (US) 2021-08-18 EP disclosed
EP-3694939-A1 WATER-DISPERSIBLE THERMOPLASTIC MATERIAL COMPRISING SULFONATED COPOLYMER FOR USE IN ADDITIVE MANUFACTURING Stratasys, Inc. (US) 2020-08-19 EP disclosed
CN-110724154-B Polysubstituted pyrrolo [3,4-d ] isoxazole derivative and synthetic method thereof 湖北科技学院 2020-08-04 CN disclosed
EP-0769522-A1 Antistatic agent for polymer compositions GENERAL ELECTRIC COMPANY (US) 1997-04-23 EP disclosed
JP-H04372613-A FLAME-RETARDING RESIN COMPOSITION NIPPON SODA CO LTD 1992-12-25 JP disclosed
EP-0295012-B1 PROCESS FOR THE PRODUCTION OF FORMED ARTICLE OF AROMATIC VINYL RESIN SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-07-08 EP disclosed
EP-0253624-B1 ACRYLIC MODIFIED N-ARYLMALEIMIDE COPOLYMER MOLDING COMPOSITION ARCO CHEMICAL TECHNOLOGY, INC. (US) 1992-03-11 EP disclosed
US-4918152-A COPOLYMERIZATION WITH A MALEIMIDE AND POLYFUNCTIONAL MONOMER; SMALL BIREFRINGENCE, HIGH REFRACTIVE INDEX; HIGH SPEED SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1990-04-17 US disclosed
EP-0295012-A2 Process for the production of formed article of aromatic vinyl resin SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1988-12-14 EP disclosed
EP-0253624-A2 Acrylic modified N-arylmaleimide copolymer molding composition ARCO CHEMICAL TECHNOLOGY, INC. (US) 1988-01-20 EP disclosed
US-4701493-A EMULSION POLYMERIZATION ATLANTIC RICHFIELD COMPANY (US) 1987-10-20 US disclosed