Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 6/20 | 0.45 |
| ▸ | DRD4 | P21917 | 5/20 | 0.45 |
| ▸ | DRD3 | P35462 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879573 | 0.85 | HTR6 (0.52) | DRD2DRD3MAPTNPSR1TDP1 | |
| SCHEMBL5879490 | 0.77 | DRD2 (0.49) | CA12CA1CA2CA9DRD2 | |
| SCHEMBL4476828 | 0.73 | CA12 (0.52) | CA12CA1CA2CA9DRD2 | |
| SCHEMBL13676941 | 0.72 | GRM5 (0.72) | MAPTL3MBTL1ALDH1A1THRB | |
| SCHEMBL4478910 | 0.70 | HTR6 (0.44) | CA12CA1CA2CA9DRD2 | |
| SCHEMBL4494237 | 0.70 | DRD2 (0.48) | CA12CA1CA2CA9DRD2 | |
| SCHEMBL3323296 | 0.67 | CASP1 (0.45) | CA12CA1CA2CA9DRD2 | |
| SCHEMBL8242932 | 0.67 | THRB (0.68) | MAPTTDP1L3MBTL1ALDH1A1HTR6 | |
| SCHEMBL13676928 | 0.67 | THRB (0.65) | MAPTTDP1L3MBTL1ALDH1A1HTR6 | |
| SCHEMBL8238195 | 0.67 | THRB (0.69) | MAPTTDP1L3MBTL1ALDH1A1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006517966-A | — | — | 2006-08-03 | — | — | JP | claimed |
| EP-1592690-A1 | HETEROCYCLYL-3-SULFONYLAZAINDOLE OR -AZAINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2005-11-09 | — | — | EP | claimed |
| WO-2004074286-A1 | HETEROCYCLYL-3-SULFONYLAZAINDOLE OR -AZAINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2004-09-02 | — | — | WO | claimed |