Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.56 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.56 |
| ▸ | ITGAL | P20701 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | BCHE | P06276 | 3/20 | 0.54 |
| ▸ | ACHE | P22303 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.54 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5880534 | 0.82 | LMNA (0.64) | ITGB2ICAM1ITGALLMNAMAPT | |
| Fumaric Acid SCHEMBL5880536 | 0.82 | LMNA (0.64) | ITGB2ICAM1ITGALLMNAMAPT | |
| SCHEMBL5880486 | 0.81 | HDAC3 (0.59) | ITGB2ICAM1ITGALLMNAMAPT | |
| SCHEMBL5880420 | 0.78 | ITGB2 (0.73) | ITGB2ICAM1ITGALLMNAMAPT | |
| SCHEMBL27083994 | 0.78 | ITGB2 (0.69) | ITGB2ICAM1ITGALLMNAMAPT | |
| SCHEMBL14697658 | 0.77 | HDAC3 (0.58) | ITGB2ICAM1ITGALLMNAMAPT | |
| SCHEMBL27083989 | 0.76 | HDAC3 (0.67) | ITGB2ICAM1ITGALLMNAMAPT | |
| Chlorpromazine SCHEMBL8701718 | 0.76 | CYP1A2 (0.81) | ITGB2ICAM1ITGALLMNAMAPT | |
| Chlorpromazine SCHEMBL8701719 | 0.76 | CYP1A2 (0.81) | ITGB2ICAM1ITGALLMNAMAPT | |
| Chlorpromazine SCHEMBL3147615 | 0.74 | CYP1A2 (0.86) | ITGB2ICAM1ITGALLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119089-B2 | Phenothiazine kinesin inhibitors | CYTOKINETICS, INC. (US) | 2006-10-10 | — | — | US | disclosed |
| US-6992082-B2 | Phenothiazine kinesin inhibitors | CYTOKINETICS, INC. (US) | 2006-01-31 | — | — | US | disclosed |
| US-20060014736-A1 | Phenothiazine kinesin inhibitors | CYTOKINETICS, INC. (US) | 2006-01-19 | — | — | US | disclosed |
| US-20040132719-A1 | Phenothiazine kinesin inhibitors | CYTOKINETICS, INC. | 2004-07-08 | — | — | US | disclosed |
| EP-1360180-A1 | PHENOTHIAZINE KINESIN INHIBITORS | Cytokinetics, Inc. (US) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002057244-A1 | PHENOTHIAZINE KINESIN INHIBITORS | CYTOKINETICS, INC. (US) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132719-A1 | Phenothiazine kinesin inhibitors | KIF5B, KIF2C, KIF15 | ITGB2 3631/4885ICAM1 921/4885ITGAL 4184/4885 |
| US-20060014736-A1 | Phenothiazine kinesin inhibitors | KIF5B, KIF2C, KIF15 | ITGB2 3728/4885ICAM1 1284/4885ITGAL 4207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.