Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bitolterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 5/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bitolterol SCHEMBL30777231 | 0.87 | LMNA (0.54) | HIF1AALDH1A1LMNACYP3A4ADRB2 | |
| Bitolterol SCHEMBL30929319 | 0.87 | LMNA (0.54) | HIF1AALDH1A1LMNACYP3A4ADRB2 | |
| Bitolterol SCHEMBL29385409 | 0.87 | LMNA (0.54) | HIF1AALDH1A1LMNACYP3A4ADRB2 | |
| Bitolterol SCHEMBL28134 | 0.87 | LMNA (0.54) | HIF1AALDH1A1LMNACYP3A4ADRB2 | |
| Bitolterol SCHEMBL28133 | 0.87 | LMNA (0.54) | HIF1AALDH1A1LMNACYP3A4ADRB2 | |
| Bitolterol SCHEMBL11286987 | 0.86 | ADRB2 (0.55) | HIF1AALDH1A1LMNACYP3A4ADRB2 | |
| Carbuterol SCHEMBL37370 | 0.84 | ADRB2 (0.58) | ADRB3HIF1ALMNACYP3A4ADRB2 | |
| Carbuterol SCHEMBL29393729 | 0.84 | ADRB2 (0.58) | ADRB3HIF1ALMNACYP3A4ADRB2 | |
| Bitolterol SCHEMBL4372 | 0.83 | LMNA (0.50) | ADRB3HIF1AALDH1A1LMNACYP3A4 | |
| Bitolterol SCHEMBL4371 | 0.83 | LMNA (0.50) | ADRB3HIF1AALDH1A1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3152328-A2 | METHODS OF DIAGNOSING CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) USING NOVEL MOLECULAR BIOMARKERS | TRANSGENION-INTERNATIONAL INSTITUTE FOR REGENERATIVE TRANSLATIONAL MEDICINE GMBH (AT) | 2017-04-12 | — | — | EP | claimed |
| WO-2015185653-A2 | METHODS OF DIAGNOSING CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) USING NOVEL MOLECULAR BIOMARKERS | MEDIZINISCHE UNIVERSITÄT WIEN (AT) | 2015-12-10 | — | — | WO | claimed |
| US-7026360-B1 | Pharmaceutical compositions containing compounds with activity for the enhancement of absorption of active ingredients | INPHARMA S.A. (CH) | 2006-04-11 | — | — | US | disclosed |