Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluacizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.61 |
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.61 |
| ▸ | TP53 | P04637 | 5/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.61 |
| ▸ | MTOR | P42345 | 4/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | HTR1A | P08908 | 4/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.61 |
| ▸ | DRD1 | P21728 | 4/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.61 |
| ▸ | DRD3 | P35462 | 4/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.61 |
| ▸ | THPO | P40225 | 3/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluacizine SCHEMBL29388364 | 0.86 | MEN1 (0.61) | TP53CYP2D6MTORCYP1A2TSHR | |
| Fluacizine SCHEMBL49497 | 0.86 | MEN1 (0.61) | TP53CYP2D6MTORCYP1A2TSHR | |
| Fluacizine SCHEMBL1650048 | 0.84 | MEN1 (0.59) | TP53CYP2D6MTORCYP1A2TSHR | |
| Triflupromazine SCHEMBL9055400 | 0.79 | TP53 (0.85) | TP53CYP2D6MTORCYP1A2TSHR | |
| SCHEMBL13305285 | 0.78 | TP53 (0.79) | TP53CYP2D6MTORCYP1A2TSHR | |
| Triflupromazine SCHEMBL32668886 | 0.77 | CYP1A2 (1.00) | TP53CYP2D6MTORCYP1A2TSHR | |
| Triflupromazine SCHEMBL44085 | 0.77 | CYP1A2 (1.00) | TP53CYP2D6MTORCYP1A2TSHR | |
| Triflupromazine SCHEMBL30903901 | 0.76 | LMNA (1.00) | TP53CYP2D6MTORCYP1A2TSHR | |
| Triflupromazine SCHEMBL29419087 | 0.76 | LMNA (1.00) | TP53CYP2D6MTORCYP1A2TSHR | |
| Triflupromazine SCHEMBL317144 | 0.76 | LMNA (1.00) | TP53CYP2D6MTORCYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7026360-B1 | Pharmaceutical compositions containing compounds with activity for the enhancement of absorption of active ingredients | INPHARMA S.A. (CH) | 2006-04-11 | — | — | US | disclosed |