Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | USP8 | P40818 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3644296 | 0.85 | ESR2 (0.40) | ESR2TSHRCYP1A2CYP1A1CYP1B1 | |
| SCHEMBL9313614 | 0.85 | ALDH1A1 (0.40) | ESR2TSHRCYP1A2CYP1A1CYP1B1 | |
| SCHEMBL27532550 | 0.85 | ESR2 (0.42) | ESR2TSHRCYP1A2CYP1A1CYP1B1 | |
| SCHEMBL2575065 | 0.84 | GABRA1 (0.39) | ESR2TSHRCYP19A1GABRG2GABRB3 | |
| SCHEMBL899 | 0.83 | CYP19A1 (0.46) | TSHRCYP1A2CYP1A1CYP1B1CYP19A1 | |
| SCHEMBL29513232 | 0.83 | CYP19A1 (0.46) | TSHRCYP1A2CYP1A1CYP1B1CYP19A1 | |
| SCHEMBL8932055 | 0.81 | CYP19A1 (0.44) | TSHRCYP1A2CYP1A1CYP1B1CYP19A1 | |
| SCHEMBL1841101 | 0.81 | SMN1; SMN2 (0.47) | TSHRCYP1A2CYP1A1CYP1B1CYP19A1 | |
| SCHEMBL7667378 | 0.80 | ESR2 (0.53) | ESR2TSHRCYP19A1ALDH1A1MAPT | |
| SCHEMBL3181745 | 0.80 | DPP4 (0.52) | ESR2TSHRCYP19A1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118271246-A | Method for continuously preparing 2-butyl-1, 3-diazaspiro [4.4] nonane-1-en-4-one | 浙江华海药业股份有限公司 | 2024-07-02 | — | — | CN | claimed |
| CN-115215813-A | Method for controlling valsartan impurity | 江苏新瑞药业有限公司 | 2022-10-21 | — | — | CN | claimed |
| CN-108732279-B | Method for analyzing and determining genotoxic impurities in valsartan by using HPLC (high performance liquid chromatography) method | 齐鲁制药有限公司 | 2022-07-08 | — | — | CN | claimed |
| CN-108732279-A | A method of it is analyzed using HPLC methods and measures genotoxicity impurity in Valsartan | 齐鲁制药有限公司 | 2018-11-02 | — | — | CN | claimed |
| CN-118271246-A | Method for continuously preparing 2-butyl-1, 3-diazaspiro [4.4] nonane-1-en-4-one | 浙江华海药业股份有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-115215813-A | Method for controlling valsartan impurity | 江苏新瑞药业有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-110156761-B | Compound containing coumarin-biphenyl skeleton, preparation method and application thereof | 郑州大学 | 2022-08-09 | — | — | CN | disclosed |
| CN-108732279-B | Method for analyzing and determining genotoxic impurities in valsartan by using HPLC (high performance liquid chromatography) method | 齐鲁制药有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-108732279-B | Method for analyzing and determining genotoxic impurities in valsartan by using HPLC (high performance liquid chromatography) method | 齐鲁制药有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-109195602-B | Symmetrical or semi-symmetrical compounds useful as immunomodulators | 上海齐鲁制药研究中心有限公司 | 2022-01-07 | — | — | CN | disclosed |
| CN-106061938-B | The manufacturing method of 2- (halogenated methyl) -3- methyl nitrobenzene | 住友化学株式会社 | 2019-04-12 | — | — | CN | disclosed |
| CN-108732279-A | A method of it is analyzed using HPLC methods and measures genotoxicity impurity in Valsartan | 齐鲁制药有限公司 | 2018-11-02 | — | — | CN | disclosed |
| US-5478840-A | Imidazo(4,5-b)pyridine derivatives used as antagonism to angiotensin ii receptors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5378701-A | Angiotensin II inhibitors; hypotensive agents; congestive heart and kidney failure; glaucoma | KYOWA HAKKO KOGYO (JP) | 1995-01-03 | — | — | US | disclosed |
| US-5369114-A | Angiotensin II antagonist | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-11-29 | — | — | US | disclosed |
| CN-1025331-C | Biphenylmethane derivative and pharmacological use | EISAI CO LTD (JP) | 1994-07-06 | — | — | CN | disclosed |
| EP-0549352-A2 | Tricyclic compounds as angiotensin II antagonists | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-06-30 | — | — | EP | disclosed |
| EP-0456442-A1 | Quinoline derivatives, process for their preparation and their use as medicaments | ZENECA LIMITED (GB) | 1991-11-13 | — | — | EP | disclosed |
| CN-1055927-A | Benzimidazole derivatives, their preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1991-11-06 | — | — | CN | disclosed |
| CN-1050539-A | Diphenyl methane derivative and medicinal | EISAI CO LTD (JP) | 1991-04-10 | — | — | CN | disclosed |