Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 7/20 | 0.33 |
| ▸ | HTR1A | P08908 | 6/20 | 0.33 |
| ▸ | HTR2B | P41595 | 6/20 | 0.33 |
| ▸ | HTR5A | P47898 | 6/20 | 0.33 |
| ▸ | HTR6 | P50406 | 6/20 | 0.33 |
| ▸ | HTR1D | P28221 | 5/20 | 0.33 |
| ▸ | HTR1B | P28222 | 5/20 | 0.33 |
| ▸ | HTR2A | P28223 | 5/20 | 0.33 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | HTR1E | P28566 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6047599 | 0.74 | IDO1 (0.39) | ALDH1A1NPC1LMNAMAPTMEN1 | |
| SCHEMBL6047614 | 0.72 | HSD11B1 (0.34) | CYP2A6HSD11B1ALDH1A1NPC1RAB9A | |
| SCHEMBL6047640 | 0.70 | MAPT (0.36) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6047643 | 0.70 | P2RX7 (0.37) | MEN1KMT2ATSHR | |
| SCHEMBL4806936 | 0.67 | ACHE (0.35) | NPC1RAB9AKMT2A | |
| SCHEMBL6047596 | 0.66 | ABL1 (0.45) | HTR7HTR1AALDH1A1NPC1RAB9A | |
| SCHEMBL4804654 | 0.66 | ACHE (0.39) | HTR2CL3MBTL1ALDH1A1NPC1RAB9A | |
| SCHEMBL4012746 | 0.63 | NOTUM (0.36) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4742508 | 0.62 | — | — | |
| SCHEMBL4015171 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037931-B2 | Corticotropin releasing factor moderator; analgesics; drug abruse, drug dependency; schizophrenia | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-02 | — | — | US | disclosed |
| US-20050026903-A1 | CCK-1 receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-03 | — | — | US | disclosed |
| US-20050020565-A1 | Pyrazole compound; gastrointestinal disorders; central nervous system disorders | JONES TODD K (US) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020565-A1 | Pyrazole compound; gastrointestinal disorders; central nervous system disorders | CCKAR, CCKBR, NPY1R | CYP2A6 561/4885HTR7 76/4885HTR1A 9/4885 |
| US-20050026903-A1 | CCK-1 receptor modulators | CCKAR, CCKBR, GLP1R | CYP2A6 985/4885HTR7 104/4885HTR1A 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.