Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887888 | 0.96 | ADAM17 (0.43) | ADAM17MMP1MMP2MMP9MMP13 | |
| SCHEMBL5887758 | 0.85 | ADAM17 (0.37) | ADAM17MMP2MMP9 | |
| Trifluoroacetic Acid SCHEMBL5887529 | 0.77 | ADAM17 (0.56) | ADAM17MMP2MMP13 | |
| Trifluoroacetic Acid SCHEMBL5887553 | 0.76 | ADAM17 (0.54) | ADAM17MMP2MMP13 | |
| SCHEMBL5887957 | 0.71 | ADAM17 (0.60) | ADAM17MMP2MMP13 | |
| SCHEMBL5935746 | 0.70 | MMP13 (0.56) | ADAM17MMP13 | |
| SCHEMBL6203455 | 0.70 | MMP13 (0.56) | ADAM17MMP13 | |
| SCHEMBL5935699 | 0.69 | ADAM17 (0.56) | ADAM17MMP1MMP2MMP9MMP13 | |
| SCHEMBL5935714 | 0.69 | ADAM17 (0.51) | ADAM17MMP1MMP2MMP9MMP13 | |
| SCHEMBL5887623 | 0.68 | ADAM17 (0.60) | ADAM17MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041693-B2 | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-09 | — | — | US | disclosed |
| US-20040067996-A1 | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE) | BRISTOL-MYERS SQUIBB COMPANY | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067996-A1 | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE) | ADAM17, ADAM9, ADAMTS1 | ADAM17 1/4885MMP1 9/4885MMP2 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.