Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 8/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL591832 | 0.97 | TDP1 (0.43) | TDP1PDPK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2518975 | 0.91 | TDP1 (0.43) | TDP1PDPK1ALDH1A1MAPTSMN1; SMN2 | |
| Water SCHEMBL11775578 | 0.88 | TDP1 (0.41) | TDP1PDPK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL29153182 | 0.88 | ALDH1A1 (0.46) | TDP1PDPK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL26312990 | 0.87 | TDP1 (0.38) | TDP1PDPK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL17628560 | 0.85 | PLAU (0.44) | TDP1PDPK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL29768708 | 0.82 | TDP1 (0.57) | TDP1PDPK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3793535 | 0.82 | TDP1 (0.57) | TDP1PDPK1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3800959 | 0.82 | GABRP (0.41) | TDP1PDPK1ALDH1A1TSHRKDM4E | |
| SCHEMBL11771827 | 0.82 | PDPK1 (0.50) | TDP1PDPK1ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 452 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116438164-B | Method for preparing 3, 6-diaminopyrazine-2, 5-dicarboxylic acid and synthetic intermediate thereof | HANGZHOU ZHONGMEI HUADONG PHARMACEUTICAL Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-114555087-B | Anodic oxidation of 5-aminouracil | 麦迪贝肯有限公司 | 2025-04-18 | — | — | CN | claimed |
| WO-2025055882-A1 | MB-102 RELATED COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2025-03-20 | — | — | WO | claimed |
| CN-117769543-A | Method for preparing pyrazine carboxylic acid derivatives as fluorescent tracers | 杭州中美华东制药有限公司 | 2024-03-26 | — | — | CN | claimed |
| EP-4313172-A1 | PREPARATION OF SUBSTITUTED DIAMINOPYRAZINE DICARBOXYLIC ACIDS | Medibeacon Inc. (US) | 2024-02-07 | — | — | EP | claimed |
| US-20240025864-A1 | METHOD FOR PREPARING 3,6-DIAMINOPYRAZINE-2,5-DICARBOXYLIC ACID AND SYNTHETIC INTERMEDIATE THEREOF | HANGZHOU ZHONGMEIHUADONG PHARMACEUTICAL CO., LTD. (CN) | 2024-01-25 | — | — | US | claimed |
| CN-117241839-A | Preparation of substituted diaminopyrazine dicarboxylic acids | 麦迪贝肯有限公司 | 2023-12-15 | — | — | CN | claimed |
| EP-4242209-A1 | METHOD FOR PREPARING 3,6-DIAMINOPYRAZINE-2,5-DICARBOXYLIC ACID AND SYNTHETIC INTERMEDIATE THEREOF | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. (CN) | 2023-09-13 | — | — | EP | claimed |
| US-11708336-B2 | Anodic oxidation of 5-aminouracil | MEDIBEACON INC. (US) | 2023-07-25 | — | — | US | claimed |
| CN-116438164-A | Method for preparing 3, 6-diaminopyrazine-2, 5-dicarboxylic acid and synthetic intermediate thereof | 杭州中美华东制药有限公司 | 2023-07-14 | — | — | CN | claimed |
| US-20160045619-A1 | METHODS OF USING OPTICAL AGENTS | MALLINCKRODT INC. | 2016-02-18 | — | — | US | claimed |
| WO-2015070256-A1 | COMPOSITIONS AND METHODS FOR ASSESSING GUT FUNCTION | DORSHOW RICHARD B (US) | 2015-05-14 | — | — | WO | claimed |
| EP-1986701-B1 | OPTICAL AGENTS FOR USE IN SURGERY | MALLINCKRODT LLC (US) | 2012-06-13 | — | — | EP | claimed |
| EP-2135863-A1 | Fluorescent pyrazine derivatives and methods of using the same in assessing renal function | Mallinckrodt, Inc. (US) | 2009-12-23 | — | — | EP | claimed |
| EP-2039688-A1 | Fluorescent pyrazine derivatives and methods of using the same in assessing renal function | Mallinckrodt, Inc. (US) | 2009-03-25 | — | — | EP | claimed |
| US-20080312539-A1 | Methods of Using Optical Agents | MEDIBEACON, INC. | 2008-12-18 | — | — | US | claimed |
| EP-1986701-A2 | PROCESS FOR USING OPTICAL AGENTS | MALLINCKRODT, INC. (US) | 2008-11-05 | — | — | EP | claimed |
| EP-1836175-A2 | FLUORESCENT PYRAZINE DERIVATIVES AND METHODS OF USING THE SAME IN ASSESSING RENAL FUNCTION | MALLINCKRODT, INC. (US) | 2007-09-26 | — | — | EP | claimed |
| WO-2007106142-A2 | PROCESS FOR USING OPTICAL AGENTS | MALLINCKRODT INC. (US) | 2007-09-20 | — | — | WO | claimed |
| WO-2006071759-A2 | FLUORESCENT PYRAZINE DERIVATIVES AND METHODS OF USING THE SAME IN ASSESSING RENAL FUNCTION | MALLINCKRODT INC. (US) | 2006-07-06 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025864-A1 | METHOD FOR PREPARING 3,6-DIAMINOPYRAZINE-2,5-DICARBOXYLIC ACID AND SYNTHETIC INTERMEDIATE THEREOF | DPYD, GART, DHODH | TDP1 1073/4885PDPK1 1559/4885ALDH1A1 731/4885 |
| US-20160045619-A1 | METHODS OF USING OPTICAL AGENTS | REN, ATP6V1B1, VHL | TDP1 3081/4885PDPK1 3819/4885ALDH1A1 2024/4885 |
| US-11708336-B2 | Anodic oxidation of 5-aminouracil | DPYD, DHODH, AASDHPPT | TDP1 1401/4885PDPK1 2395/4885ALDH1A1 297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.