Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 12/20 | 0.77 |
| ▸ | TUBB | P07437 | 12/20 | 0.77 |
| ▸ | TUBA3C | P0DPH7 | 12/20 | 0.77 |
| ▸ | TUBA1B | P68363 | 12/20 | 0.77 |
| ▸ | TUBA4A | P68366 | 12/20 | 0.77 |
| ▸ | TUBB4B | P68371 | 12/20 | 0.77 |
| ▸ | TUBB3 | Q13509 | 12/20 | 0.77 |
| ▸ | TUBB2A | Q13885 | 12/20 | 0.77 |
| ▸ | TUBB8 | Q3ZCM7 | 12/20 | 0.77 |
| ▸ | TUBA3E | Q6PEY2 | 12/20 | 0.77 |
| ▸ | TUBA1A | Q71U36 | 12/20 | 0.77 |
| ▸ | TUBA1C | Q9BQE3 | 12/20 | 0.77 |
| ▸ | TUBB6 | Q9BUF5 | 12/20 | 0.77 |
| ▸ | TUBB2B | Q9BVA1 | 12/20 | 0.77 |
| ▸ | TUBB1 | Q9H4B7 | 12/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5889261 | 0.87 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4772008 | 0.86 | TUBB4A (0.59) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5812212 | 0.81 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5809749 | 0.81 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5811856 | 0.80 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4591940 | 0.76 | ALDH1A1 (0.67) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5809644 | 0.76 | TUBB4A (0.80) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5812739 | 0.74 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL14174310 | 0.74 | KDM4E (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4592152 | 0.72 | KDM4E (0.61) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074814-B2 | 3-substituted indoles and derivatives thereof as therapeutic agents | WARNER-LAMBERT COMPANY LLC (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1644360-A1 | 3-SUBSTITUTED INDOLES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | Warner-Lambert Company LLC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-20050004195-A1 | 3-Substituted indoles and derivatives thereof as therapeutic agents | PARA KIMBERLY SUZANNE (US) | 2005-01-06 | — | — | US | disclosed |
| WO-2004108708-A1 | 3-SUBSTITUTED INDOLES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004195-A1 | 3-Substituted indoles and derivatives thereof as therapeutic agents | IDO1, TPH1, IDO2 | TUBB4A 3259/4885TUBB 3222/4885TUBA3C 2949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.