Sugi Predict

Sugi Predict / Compounds / SCHEMBL5889273

SCHEMBL5889273

SCHEMBL5889273

C[Si](C)(c1ccccc1)C1/C=C\CCCCC1

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ NR1H2 P55055 1/20 0.33
▸ NR1H3 Q13133 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ APOBEC3G Q9HC16 1/20 0.31
▸ POLB P06746 1/20 0.31
▸ CASP3 P42574 1/20 0.31
▸ SENP7 Q9BQF6 1/20 0.31
▸ SENP6 Q9GZR1 1/20 0.31
▸ OPRM1 P35372 2/20 0.31
▸ OPRD1 P41143 2/20 0.31
▸ OPRK1 P41145 2/20 0.31
▸ OGFRL1 Q5TC84 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5889275 1.00 NR1H2 (0.33) NR1H2NR1H3CYP2C19ALDH1A1HPGD
SCHEMBL5889119 0.98 CYP2C19 (0.34) NR1H2NR1H3CYP2C19ALDH1A1HPGD
SCHEMBL5889156 0.93 ALDH1A1 (0.35) CYP2C19ALDH1A1HPGDAPOBEC3G
SCHEMBL5889253 0.85 CYP2C19 (0.37) NR1H2NR1H3CYP2C19
SCHEMBL6512866 0.75 — —
SCHEMBL6512869 0.75 — —
SCHEMBL2622738 0.74 NR1H2 (0.54) NR1H2NR1H3ALDH1A1HPGDPOLB
SCHEMBL23532540 0.73 — —
SCHEMBL19622284 0.71 CES2 (0.32) ALDH1A1HPGDPOLB
SCHEMBL29941783 0.69 POLB (0.34) NR1H2NR1H3POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060194827-A1 5-Cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds LIGAND PHARMACEUTICALS, INCORPORATED 2006-08-31 — — US disclosed
US-7071205-B2 5-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds LIGAND PHARMACEUTICALS INCORPORATED (US) 2006-07-04 — — US disclosed
EP-1551845-A1 5-CYCLOALKENYL 5 i H /i -CHROMENO 3,4-F QUINOLINE DERIV ATIVES AS SELECTIVE PROGESTERONE RECEPTOR MODULATOR COMPOUNDS LIGAND PHARMACEUTICALS, INC. (US) 2005-07-13 — — EP disclosed
US-20040152718-A1 5-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2004-08-05 — — US disclosed
WO-2004033460-A1 5-CYCLOALKENYL 5H-CHROMENO[3,4-F]QUINOLINE DERIVATIVES AS SELECTIVE PROGESTERONE RECEPTOR MODULATOR COMPOUNDS LIGAND PHARMACEUTICALS INCORPORATED (US) 2004-04-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060194827-A1 5-Cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds PGR, GPER1, FSHR NR1H2 33/4885NR1H3 41/4885CYP2C19 646/4885
US-20040152718-A1 5-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds PGR, GPER1, PGRMC2 NR1H2 21/4885NR1H3 28/4885CYP2C19 246/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.