Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 9/20 | 0.52 |
| ▸ | MMP13 | P45452 | 9/20 | 0.52 |
| ▸ | MMP1 | P03956 | 7/20 | 0.52 |
| ▸ | MMP12 | P39900 | 5/20 | 0.52 |
| ▸ | MMP7 | P09237 | 3/20 | 0.52 |
| ▸ | MMP9 | P14780 | 5/20 | 0.46 |
| ▸ | MMP3 | P08254 | 4/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP10 | P09238 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyamine SCHEMBL6529639 | 0.88 | FKBP1A (0.41) | MMP8MMP13MMP1MMP12MMP7 | |
| Hydroxyamine SCHEMBL5894541 | 0.76 | FKBP1A (0.52) | MMP8MMP13MMP1MMP12MMP7 | |
| SCHEMBL6667249 | 0.69 | MMP13 (0.51) | MMP8MMP13MMP1MMP12MMP7 | |
| Hydrochloric Acid SCHEMBL28277924 | 0.65 | MGLL (0.47) | — | |
| SCHEMBL6598977 | 0.64 | MGLL (0.49) | — | |
| SCHEMBL27672018 | 0.64 | SLC6A2 (0.48) | MMP8MMP13MMP1MMP12MMP7 | |
| SCHEMBL1873557 | 0.64 | SLC6A2 (0.42) | — | |
| SCHEMBL1873560 | 0.64 | SLC6A2 (0.42) | — | |
| SCHEMBL22070850 | 0.63 | MGLL (0.48) | — | |
| SCHEMBL22071071 | 0.63 | CA2 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030242-B2 | Selective inhibition of aggrecanase in osteoarthritis treatment | PFIZER INC (US) | 2006-04-18 | — | — | US | disclosed |