Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21547790 | 0.81 | TSHR (0.49) | TSHRCYP19A1KDM4ESMN1; SMN2HMOX2 | |
| SCHEMBL5865713 | 0.79 | CYP19A1 (0.57) | TSHRCYP19A1KDM4EEGLN1SLC6A2 | |
| SCHEMBL3996750 | 0.78 | CYP19A1 (0.46) | TSHRCYP19A1KDM4ESLC6A2SLC6A4 | |
| SCHEMBL23343730 | 0.76 | TSHR (0.43) | TSHRCYP19A1KDM4EHMOX2EGLN1 | |
| SCHEMBL28827501 | 0.76 | TSHR (0.43) | TSHRCYP19A1KDM4ESMN1; SMN2SLC6A2 | |
| SCHEMBL730575 | 0.76 | TSHR (0.43) | TSHRCYP19A1KDM4EHMOX2EGLN1 | |
| SCHEMBL15174490 | 0.76 | CYP2D6 (0.45) | TSHRCYP19A1KDM4ELMNA | |
| SCHEMBL22369257 | 0.76 | CYP2D6 (0.45) | TSHRCYP19A1KDM4ELMNA | |
| SCHEMBL5134511 | 0.76 | LMNA (0.46) | TSHRCYP19A1KDM4EHMOX2EGLN1 | |
| SCHEMBL11499232 | 0.73 | TSHR (0.41) | TSHRCYP19A1HMOX2EGLN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1317966-A | Use of derivatives of aryl (or heteroaryl) pyrrolylcarbinol for the manufacture of a medicament for the treatment of diseases mediated by an excess of substance P | ESTEVE LABOR DR (ES) | 2001-10-17 | — | — | CN | claimed |
| US-20160347716-A1 | Water-Soluble Pyrazole Derivatives as Corrosion Inhibitors | ECOLAB USA INC. (US) | 2016-12-01 | — | — | US | disclosed |
| WO-2016191677-A1 | WATER-SOLUBLE PYRAZOLE DERIVATIVES AS CORROSION INHIBITORS | ECOLAB USA INC. (US) | 2016-12-01 | — | — | WO | disclosed |
| US-7129361-B2 | Thienylazolylalkoxyethanamines, their preparation and their application as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-10-31 | — | — | US | disclosed |
| EP-1072266-B1 | THIENYLAZOLYLALCOXYETHANAMINES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2005-08-24 | — | — | EP | disclosed |
| US-20040162324-A1 | Thienylazolylalkoxyethanamines, their preparation and their application as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. | 2004-08-19 | — | — | US | disclosed |
| US-20020188017-A1 | Thienylazolylalkoxyethanamines, their preparation and their application as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. | 2002-12-12 | — | — | US | disclosed |
| US-6410582-B1 | ANALGESICS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2002-06-25 | — | — | US | disclosed |
| EP-1072266-A1 | THIENYLAZOLYLALCOXYETHANAMINES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2001-01-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160347716-A1 | Water-Soluble Pyrazole Derivatives as Corrosion Inhibitors | BLVRB, CAT, PPOX | TSHR 1860/4885CYP19A1 412/4885KDM4E 4637/4885 |
| US-20020188017-A1 | Thienylazolylalkoxyethanamines, their preparation and their application as medicaments | HNMT, HRH4, PNMT | TSHR 351/4885CYP19A1 2812/4885KDM4E 1013/4885 |
| US-20040162324-A1 | Thienylazolylalkoxyethanamines, their preparation and their application as medicaments | HNMT, HRH4, PNMT | TSHR 351/4885CYP19A1 2812/4885KDM4E 1013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.