Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | PTPRC | P08575 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16253828 | 0.81 | PGK1 (0.52) | — | |
| SCHEMBL2030739 | 0.79 | CA1 (0.49) | CA1CA2CES1CES2PTPRC | |
| SCHEMBL3230183 | 0.79 | PTPRC (0.51) | CA1CA2CES1CES2PTPRC | |
| SCHEMBL2637314 | 0.79 | PTPRC (0.51) | CA1CA2CES1CES2PTPRC | |
| SCHEMBL2636706 | 0.79 | PGK1 (0.67) | CA1CA2CES1CES2HSD11B1 | |
| Phosphoric Acid SCHEMBL28639141 | 0.79 | CA1 (0.65) | CA1CA2CES1CES2CA12 | |
| SCHEMBL78562 | 0.75 | ALDH1A1 (0.51) | CA1CA2CES1CES2PTPRC | |
| SCHEMBL11029750 | 0.74 | PTPRC (0.43) | CA1CA2CES1CES2PTPRC | |
| SCHEMBL1023276 | 0.74 | HSD11B1 (0.60) | CA1CA2CES1HSD11B1CYP19A1 | |
| SCHEMBL11026039 | 0.74 | CES1 (0.54) | CA1CA2CES1CES2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005533-B2 | Bisphosphonate derivatives, their preparations and uses | UNIVERSITE PARIS 13 (FR) | 2006-02-28 | — | — | US | disclosed |
| US-20040266735-A1 | Bisphosphonate derivatives, their preparations and uses | UNIVERSITE PARIS 13 | 2004-12-30 | — | — | US | disclosed |
| US-20030036537-A1 | Bisphosphonate derivatives, their preparations and uses | UNIVERSITE PARIS, 13 (FR) | 2003-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030036537-A1 | Bisphosphonate derivatives, their preparations and uses | BPGM, PPIP5K2, PTEN | CA1 3133/4885CA2 1168/4885CES1 2004/4885 |
| US-20040266735-A1 | Bisphosphonate derivatives, their preparations and uses | BPGM, PPIP5K2, PTEN | CA1 3133/4885CA2 1168/4885CES1 2004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.