Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.38 |
| ▸ | LPL | P06858 | 4/20 | 0.38 |
| ▸ | P4HB | P07237 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58297 | 0.88 | AAK1 (0.44) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL59978 | 0.86 | ROCK1 (0.42) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL58724 | 0.84 | CSF1R (0.39) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL21626168 | 0.82 | LIPG (0.41) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL2136697 | 0.79 | LIPG (0.46) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL4753530 | 0.77 | LIPG (0.40) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL20660620 | 0.76 | BACE1 (0.47) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL1554719 | 0.75 | DGAT1 (0.37) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL15788274 | 0.75 | LPL (0.43) | F11LIPGLPLCA1CA2 | |
| SCHEMBL2157168 | 0.74 | LIPG (0.37) | F11F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143393-B2 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2012-03-27 | — | — | US | disclosed |