Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | F11 | P03951 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 4/20 | 0.37 |
| ▸ | LPL | P06858 | 3/20 | 0.37 |
| ▸ | P4HB | P07237 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59027 | 0.88 | F11 (0.39) | AAK1F2F11PRSS1PRSS2 | |
| SCHEMBL58724 | 0.85 | CSF1R (0.39) | AAK1F2F11PRSS1PRSS2 | |
| SCHEMBL59978 | 0.85 | ROCK1 (0.42) | AAK1F2F11PRSS1PRSS2 | |
| SCHEMBL2136697 | 0.78 | LIPG (0.46) | AAK1F2F11PRSS1PRSS2 | |
| SCHEMBL1131421 | 0.76 | TSHR (0.47) | AAK1F2F11PRSS1PRSS2 | |
| SCHEMBL4753530 | 0.76 | LIPG (0.40) | AAK1F2F11PRSS1PRSS2 | |
| SCHEMBL15788035 | 0.76 | LPL (0.42) | AAK1F11LIPGLPLCA1 | |
| SCHEMBL18497287 | 0.75 | AAK1 (0.40) | AAK1F2F11PRSS1PRSS2 | |
| SCHEMBL2562627 | 0.75 | AAK1 (0.47) | AAK1F2F11PRSS1PRSS2 | |
| SCHEMBL1554719 | 0.74 | DGAT1 (0.37) | AAK1F2F11PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143393-B2 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2012-03-27 | — | — | US | disclosed |