Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 1-Hexanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.44 |
| ▸ | PPARG | P37231 | 7/20 | 0.44 |
| ▸ | PPARD | Q03181 | 7/20 | 0.44 |
| ▸ | PPARA | Q07869 | 7/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyl Alcohol SCHEMBL7054591 | 0.91 | ALDH1A1 (0.55) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| Myristyl Alcohol SCHEMBL27619355 | 0.91 | TSHR (0.72) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| Decane SCHEMBL11801810 | 0.91 | GPR84 (0.52) | TSHRALDH1A1HSD17B10MEN1KMT2A | |
| Heptane SCHEMBL4552753 | 0.91 | GPR84 (0.52) | TSHRALDH1A1HSD17B10MEN1KMT2A | |
| Octanol SCHEMBL5159414 | 0.91 | TSHR (0.72) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| Hexadecane SCHEMBL11801817 | 0.91 | GPR84 (0.52) | TSHRALDH1A1HSD17B10MEN1KMT2A | |
| 1-Hexanol SCHEMBL28299651 | 0.91 | TSHR (0.72) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| Cetostearyl Alcohol SCHEMBL28119730 | 0.91 | TSHR (0.72) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| Dodecanol SCHEMBL10801052 | 0.91 | TSHR (0.72) | TSHRALDH1A1LMNAHSD17B10MEN1 | |
| Dodecanol SCHEMBL9228924 | 0.88 | TSHR (0.68) | TSHRALDH1A1LMNAHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060083701-A1 | Nail enamel compositions, related methods, and a two component kit for painting the nails | REVLON CONSUMER PRODUCTS CORPORATION (US) | 2006-04-20 | — | — | US | disclosed |
| US-6896877-B2 | Cosmetic compositions containing crosslinkable polymers | REVLON CONSUMER PRODUCTS CORPORATION (US) | 2005-05-24 | — | — | US | disclosed |
| US-20040105876-A1 | Cosmetic compositions containing crosslinkable polymers | REVLON CONSUMER PRODUCTS CORPORATION | 2004-06-03 | — | — | US | disclosed |
| US-20030049215-A1 | Method for improving integrity of cosmetic films | REVLON CONSUMER PRODUCTS CORPORATION | 2003-03-13 | — | — | US | disclosed |
| US-6485731-B2 | CONDITIONING NAILS OR SURROUNDING CUTICLE WITH A COMPOSITION THAT HAS < 5% OF A FLUORINATED SILICONE OIL | REVLON CONSUMER PRODUCTS CORPORATION | 2002-11-26 | — | — | US | disclosed |
| US-20020136745-A1 | Method for improving integrity of cosmetic films | CITICORP USA, INC. | 2002-09-26 | — | — | US | disclosed |
| US-6342209-B1 | NAIL ENAMEL COMPOSITION CONTAINING AT LEAST ONE FILM FORMING POLYMER, AT LEAST ONE SOLVENT, PLASTICIZER FOR FILM FORMING POLYMER WHICH IS LOWER ALKYL ESTER OF MALIC ACID | REVLON CONSUMER PRODUCTS CORPORATION | 2002-01-29 | — | — | US | disclosed |
| US-20020004054-A1 | Cosmetic compositions containing crosslinkable polymers | REVLON CONSUMER PRODUCTS CORPORATION (US) | 2002-01-10 | — | — | US | disclosed |
| US-6277358-B1 | Cosmetic compositions containing crosslinkable polymers | REVLON CONSUMER PRODUCTS CORPORATION | 2001-08-21 | — | — | US | disclosed |
| US-5772988-A | SOLVENT AND METHACRYLATE COPOLYMER FOR NAIL ENAMELS AND KITS | REVLON CONSUMER PRODUCTS CORPORATION (US) | 1998-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040105876-A1 | Cosmetic compositions containing crosslinkable polymers | KRT18, CUTA, DSG1 | TSHR 3865/4885ALDH1A1 1738/4885LMNA 601/4885 |
| US-20030049215-A1 | Method for improving integrity of cosmetic films | CUTA, TYR, POLR1C | TSHR 2795/4885ALDH1A1 2491/4885LMNA 778/4885 |
| US-20020004054-A1 | Cosmetic compositions containing crosslinkable polymers | CUTA, KRT18, DSG1 | TSHR 3868/4885ALDH1A1 1867/4885LMNA 610/4885 |
| US-20060083701-A1 | Nail enamel compositions, related methods, and a two component kit for painting the nails | PIK3C3, POLR1C, PRKDC | TSHR 4549/4885ALDH1A1 3385/4885LMNA 1685/4885 |
| US-20020136745-A1 | Method for improving integrity of cosmetic films | CUTA, TYR, POLR1C | TSHR 2795/4885ALDH1A1 2491/4885LMNA 778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.