SCHEMBL5905902

SCHEMBL5905902

O=c1[nH]cnn1-c1ccccc1F

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
MGLL Q99685 1/20 0.43
SCN9A Q15858 3/20 0.42
HCAR1 Q9BXC0 4/20 0.40
MAPK14 Q16539 1/20 0.39
KCNN4 O15554 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
PARP1 P09874 1/20 0.38
HSP90AA1 P07900 1/20 0.38
SCN10A Q9Y5Y9 1/20 0.37
PDE4A P27815 1/20 0.37
PDE4B Q07343 1/20 0.37
PDE4C Q08493 1/20 0.37
PDE4D Q08499 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4700339 0.80 MGLL (0.44) MGLLHCAR1MAPK14SMN1; SMN2
SCHEMBL5906118 0.78 MAPT (0.48) MEN1KMT2AHCAR1PARP1PDE4A
SCHEMBL28874777 0.73 NPC1 (0.44) SMN1; SMN2PARP1
SCHEMBL461726 0.73 ALDH1A1 (0.46) SMN1; SMN2
SCHEMBL5906106 0.71 MEN1 (0.47) MEN1KMT2AMGLLSCN9AHCAR1
SCHEMBL28471419 0.70 CCNE1 (0.38) MGLLHCAR1SMN1; SMN2PARP1
SCHEMBL30745145 0.69 MGLL (0.44) MEN1KMT2AMGLLSCN9AMAPK14
SCHEMBL5906032 0.69 ALDH1A1 (0.46) MEN1KMT2AMGLLMAPK14
SCHEMBL6658181 0.69 ADORA3 (0.48) MEN1KMT2AMGLLHCAR1KCNN4
SCHEMBL10811779 0.69 GAA (0.52) MEN1KMT2AMGLLHCAR1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060223872-A1 Insecticidal phthalamide derivatives BAYER CROPSCIENCE AG (DE) 2006-10-05 US disclosed
EP-1606271-A1 INSECTICIDAL PHTHALAMIDE DERIVATIVES Bayer CropScience AG (DE) 2005-12-21 EP disclosed
WO-2004080984-A1 INSECTICIDAL PHTHALAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2004-09-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060223872-A1 Insecticidal phthalamide derivatives CRYAA, PRXL2A, H1-2 MEN1 477/4885KMT2A 53/4885MGLL 2851/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.