Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | STIM1 | Q13586 | 4/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 4/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5912735 | 0.82 | CASP6 (0.41) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL15533833 | 0.81 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5912149 | 0.77 | BTK (0.45) | PDE4APDE4BPDE4CPDE4DSTIM1 | |
| SCHEMBL5912652 | 0.74 | L3MBTL1 (0.43) | CLK1DYRK1ADYRK2DYRK1BGAA | |
| SCHEMBL5912776 | 0.73 | ALDH1A1 (0.41) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5912780 | 0.73 | ALDH1A1 (0.41) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL22272084 | 0.71 | JAK3 (0.44) | JAK2JAK1JAK3 | |
| SCHEMBL5912176 | 0.71 | CYP2A6 (0.50) | CYP2A6CYP3A4CYP2B6CYP2C19ALDH1A1 | |
| SCHEMBL5912875 | 0.70 | PIN1 (0.46) | POLBCYP3A4CYP2C19GAAALDH1A1 | |
| SCHEMBL22261251 | 0.69 | JAK2 (0.54) | JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060194811-A1 | Pyrimidine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-08-31 | — | — | US | disclosed |
| EP-1595869-A1 | PYRIMIDINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2005-11-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194811-A1 | Pyrimidine derivatives | ADORA3, NR4A1, NR0B1 | PDE4A 3011/4885PDE4B 3448/4885PDE4C 3235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.