Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.51 |
| ▸ | CYP2E1 | P05181 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 5/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.51 |
| ▸ | CYP2B6 | P20813 | 5/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.51 |
| ▸ | PTGES | O14684 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5915139 | 0.85 | GPR84 (0.39) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL5915172 | 0.83 | ALDH1A1 (0.38) | CYP3A4MAPTGPR84 | |
| SCHEMBL4192105 | 0.79 | CYP1A2 (0.41) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL4027604 | 0.78 | CTSB (0.55) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL5915134 | 0.77 | GPR84 (0.41) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL5915188 | 0.77 | NPC1 (0.47) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL5915225 | 0.74 | GPR84 (0.40) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL4201055 | 0.74 | CYP1A2 (0.53) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL5915168 | 0.74 | NPC1 (0.42) | CYP1A2CYP2E1CYP3A4CYP2C8CYP2D6 | |
| SCHEMBL5915166 | 0.73 | GPR84 (0.43) | MAPTNPC1RAB9AGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060247280-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2006-11-02 | — | — | US | claimed |
| US-20060247280-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2006-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247280-A1 | Compounds and methods | METAP2, DNPEP, METAP1 | CYP1A2 2772/4885CYP2E1 4041/4885CYP3A4 3320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.