Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.44 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.44 |
| ▸ | SNRK | Q9NRH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5923438 | 0.86 | KDM4E (0.56) | SMN1; SMN2RAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL4115898 | 0.83 | RAB9A (0.71) | SMN1; SMN2RAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL5923423 | 0.82 | RAB9A (0.49) | SMN1; SMN2RAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL5922942 | 0.80 | ALDH1A1 (0.50) | SMN1; SMN2RAB9ANPC1ALDH1A1TP53 | |
| SCHEMBL6155127 | 0.78 | SRC (0.53) | SMN1; SMN2RAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL5923267 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL5923336 | 0.76 | TP53 (0.52) | SMN1; SMN2RAB9ANPC1KMT2ATP53 | |
| SCHEMBL5923212 | 0.76 | ALDH1A1 (0.49) | SMN1; SMN2RAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL5923619 | 0.76 | KMT2A (0.54) | SMN1; SMN2RAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL5923218 | 0.74 | KDM4E (0.46) | SMN1; SMN2RAB9ANPC1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2006-05-11 | — | — | US | claimed |
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | PIGS, GUCY1A1, GUCY1B1 | SMN1; SMN2 1226/4885RAB9A 410/4885NPC1 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.