Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GCK | P35557 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5923264 | 0.90 | CYP1A2 (0.52) | SMN1; SMN2LMNAKDM4EHTTTP53 | |
| SCHEMBL5923336 | 0.89 | TP53 (0.52) | SMN1; SMN2KDM4ETP53NPC1RAB9A | |
| SCHEMBL5923207 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAKDM4EHTTALDH1A1 | |
| SCHEMBL5923241 | 0.81 | EPHX2 (0.49) | SMN1; SMN2LMNAKDM4EHTTALDH1A1 | |
| SCHEMBL5922942 | 0.79 | ALDH1A1 (0.50) | SMN1; SMN2TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL5923375 | 0.79 | CYP1A2 (0.51) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL4979481 | 0.78 | HPGD (0.59) | SMN1; SMN2LMNAHTTTP53ALDH1A1 | |
| SCHEMBL5923310 | 0.78 | RAB9A (0.52) | SMN1; SMN2LMNAKDM4EHTTTP53 | |
| SCHEMBL5923009 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAKDM4ETP53ALDH1A1 | |
| SCHEMBL5923222 | 0.77 | NPSR1 (0.49) | SMN1; SMN2LMNAHTTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2006-05-11 | — | — | US | claimed |
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | PIGS, GUCY1A1, GUCY1B1 | SMN1; SMN2 1226/4885LMNA 620/4885KDM4E 1667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.