Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.38 |
| ▸ | S100A10 | P60903 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5923518 | 0.93 | SMN1; SMN2 (0.49) | SMN1; SMN2KCNH2MAPTALDH1A1MEN1 | |
| SCHEMBL5923286 | 0.90 | ALDH1A1 (0.47) | SMN1; SMN2KCNH2MAPTALDH1A1MEN1 | |
| SCHEMBL5923234 | 0.89 | SMN1; SMN2 (0.48) | TSHRSMN1; SMN2MAPTALDH1A1MEN1 | |
| SCHEMBL4099597 | 0.82 | LMNA (0.49) | POLBKDM4ELMNA | |
| SCHEMBL5923231 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5923153 | 0.81 | HTT (0.46) | TSHRSMN1; SMN2MAPTALDH1A1MEN1 | |
| SCHEMBL5923278 | 0.80 | ALDH1A1 (0.49) | TSHRSMN1; SMN2KCNH2MAPTALDH1A1 | |
| SCHEMBL5923283 | 0.80 | MAPT (0.58) | TSHRSMN1; SMN2SLC2A1MAPTALDH1A1 | |
| SCHEMBL5923337 | 0.80 | SCN9A (0.51) | KCNH2MEN1KMT2AHTTPOLB | |
| SCHEMBL5923240 | 0.80 | SMN1; SMN2 (0.50) | TSHRSMN1; SMN2MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2006-05-11 | — | — | US | claimed |
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | PIGS, GUCY1A1, GUCY1B1 | TSHR 1803/4885SMN1; SMN2 1226/4885KCNH2 1241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.