Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 2/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | PNLIP | P16233 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5923368 | 0.91 | CRHBP (0.50) | ALDH1A1SMN1; SMN2CRHBPCRHR2MAPT | |
| SCHEMBL5923253 | 0.90 | RAB9A (0.51) | ALDH1A1SMN1; SMN2POLBCRHBPCRHR2 | |
| SCHEMBL5923286 | 0.89 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2POLBMAPTMEN1 | |
| SCHEMBL5923283 | 0.85 | MAPT (0.58) | ALDH1A1SMN1; SMN2POLBCRHBPCRHR2 | |
| SCHEMBL5923234 | 0.81 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2POLBCRHBPCRHR2 | |
| SCHEMBL13856226 | 0.80 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2CRHBPCRHR2MAPT | |
| SCHEMBL5923192 | 0.80 | TSHR (0.47) | ALDH1A1SMN1; SMN2POLBMAPTMEN1 | |
| SCHEMBL17988142 | 0.80 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2POLBCRHBPCRHR2 | |
| SCHEMBL5923002 | 0.80 | MAPT (0.57) | ALDH1A1SMN1; SMN2POLBCRHBPCRHR2 | |
| SCHEMBL13310313 | 0.80 | MAPT (0.52) | ALDH1A1CRHBPCRHR2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2006-05-11 | — | — | US | claimed |
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | PIGS, GUCY1A1, GUCY1B1 | ALDH1A1 535/4885SMN1; SMN2 1226/4885POLB 2292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.