Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.49 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.45 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.45 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.45 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5923119 | 0.91 | HTT (0.48) | EPHX2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL2801059 | 0.89 | ALDH1A1 (0.48) | ALDH1A1LMNAKDM4E | |
| SCHEMBL5923299 | 0.87 | EPHX2 (0.46) | EPHX2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL5923374 | 0.86 | EPHX2 (0.45) | EPHX2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL5923332 | 0.85 | EPHX2 (0.49) | EPHX2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL5923285 | 0.84 | EPHX2 (0.46) | EPHX2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL5923485 | 0.82 | KDM4E (0.58) | EPHX2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL5923323 | 0.81 | EPHX2 (0.43) | EPHX2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL5923253 | 0.80 | RAB9A (0.51) | CYP1A2MAPTCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL5923241 | 0.78 | EPHX2 (0.49) | EPHX2PLAAT3PLAAT5PLAAT2PLAAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2006-05-11 | — | — | US | claimed |
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |
| US-20140322160-A1 | METHOD AND COMPOSITION FOR ALTERING A B CELL MEDIATED PATHOLOGY | MMRGLOBAL, INC. (US) | 2014-10-30 | — | — | US | disclosed |
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2006-05-11 | — | — | US | disclosed |
| US-20050238645-A1 | Method and composition for altering a B cell mediated pathology | FAVRILLE, INC. | 2005-10-27 | — | — | US | disclosed |
| WO-2000040606-A2 | MODULATION OF HIV REPLICATION USING SAM68 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-07-13 | — | — | WO | disclosed |
| EP-0586549-A1 | SELECTING LIGAND AGONISTS AND ANTAGONISTS | GENENTECH, INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021029-A1 | SELECTING LIGAND AGONISTS AND ANTAGONISTS | GENENTECH, INC. (US) | 1992-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100225-A1 | Heteroaryl guanidines; inhibitors of viral replication | PIGS, GUCY1A1, GUCY1B1 | EPHX2 3096/4885PLAAT3 993/4885PLAAT5 2045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.