Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | CA12 | O43570 | 2/20 | 0.62 |
| ▸ | CA1 | P00915 | 2/20 | 0.62 |
| ▸ | CA2 | P00918 | 2/20 | 0.62 |
| ▸ | CA7 | P43166 | 2/20 | 0.62 |
| ▸ | CA9 | Q16790 | 2/20 | 0.62 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27489328 | 0.88 | SMN1; SMN2 (0.52) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL3299225 | 0.88 | CA12 (0.62) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL7723906 | 0.88 | SMN1; SMN2 (0.68) | SMN1; SMN2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL426382 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL17881359 | 0.86 | TDP1 (0.54) | SMN1; SMN2ALDH1A1KMT2ATP53TDP1 | |
| SCHEMBL6750268 | 0.85 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL7791316 | 0.84 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL8490992 | 0.84 | TDP1 (0.70) | SMN1; SMN2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL2062103 | 0.84 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL26687978 | 0.84 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060110743-A1 | Drug evolution: drug design at hot spots | KONISHI YASUO | 2006-05-25 | — | — | US | claimed |
| WO-2002095393-A2 | DRUG EVOLUTION: DRUG DESIGN AT HOT SPOTS | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2002-11-28 | — | — | WO | claimed |
| US-20110124685-A1 | Anesthetic Compounds | SIGNATURE THERAPEUTICS, INC. | 2011-05-26 | — | — | US | disclosed |
| US-20110124685-A1 | Anesthetic Compounds | SIGNATURE THERAPEUTICS, INC. | 2011-05-26 | — | — | US | disclosed |
| US-20100056575-A1 | Anesthetic Compounds | SIGNATURE THERAPEUTICS, INC. | 2010-03-04 | — | — | US | disclosed |
| US-20100056575-A1 | Anesthetic Compounds | SIGNATURE THERAPEUTICS, INC. | 2010-03-04 | — | — | US | disclosed |
| WO-2009091546-A1 | ANESTHETIC COMPOUNDS | PHARMACOFORE, INC. (US) | 2009-07-23 | — | — | WO | disclosed |
| WO-2008011539-A2 | ANESTHETIC COMPOUNDS | PHARMACOFORE, INC. (US) | 2008-01-24 | — | — | WO | disclosed |
| US-20060110743-A1 | Drug evolution: drug design at hot spots | KONISHI YASUO | 2006-05-25 | — | — | US | disclosed |
| WO-2002095393-A2 | DRUG EVOLUTION: DRUG DESIGN AT HOT SPOTS | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2002-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056575-A1 | Anesthetic Compounds | OPRL1, OPRM1, CYP3A5 | SMN1; SMN2 1270/4885CA12 493/4885CA1 22/4885 |
| US-20110124685-A1 | Anesthetic Compounds | TRPA1, TRPV1, OPRL1 | SMN1; SMN2 3068/4885CA12 2530/4885CA1 795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.