Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.60 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4420346 | 0.88 | SMN1; SMN2 (0.64) | TDP1SMN1; SMN2PKMMAPTMAPK1 | |
| SCHEMBL7723906 | 0.86 | SMN1; SMN2 (0.68) | TDP1SMN1; SMN2MAPTALDH1A1ADRB2 | |
| SCHEMBL2984468 | 0.86 | TDP1 (0.64) | TDP1SMN1; SMN2PKMMAPTMAPK1 | |
| SCHEMBL426382 | 0.85 | SMN1; SMN2 (0.67) | TDP1SMN1; SMN2MAPTMAPK1POLB | |
| SCHEMBL31534624 | 0.84 | TDP1 (0.72) | TDP1SMN1; SMN2PKMMAPTMAPK1 | |
| SCHEMBL6750268 | 0.84 | SMN1; SMN2 (0.65) | TDP1SMN1; SMN2MAPTMAPK1POLB | |
| SCHEMBL5925545 | 0.84 | SMN1; SMN2 (0.65) | TDP1SMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL11278115 | 0.83 | TDP1 (0.57) | TDP1SMN1; SMN2PKMMAPTMAPK1 | |
| SCHEMBL3506460 | 0.83 | SMN1; SMN2 (0.61) | TDP1SMN1; SMN2MAPTALDH1A1KMT2A | |
| SCHEMBL222270 | 0.83 | TDP1 (0.67) | TDP1SMN1; SMN2PKMMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190177284-A1 | TETRAZOLYL-CONTAINING CYCLOPROPANECARBOXAMIDES | Bayer Pharma AG (DE) | 2019-06-13 | — | — | US | disclosed |
| US-20190177284-A1 | TETRAZOLYL-CONTAINING CYCLOPROPANECARBOXAMIDES | Bayer Pharma AG (DE) | 2019-06-13 | — | — | US | disclosed |
| EP-2565182-B1 | NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-10-11 | — | — | EP | disclosed |
| US-8816079-B2 | Amide derivative and use thereof as medicine | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2014-08-26 | — | — | US | disclosed |
| EP-2565182-A1 | NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE | Mitsubishi Tanabe Pharma Corporation (JP) | 2013-03-06 | — | — | EP | disclosed |
| US-20130040930-A1 | NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-02-14 | — | — | US | disclosed |
| US-5859283-A | TERTIARY-BUTYL 3-CYCLOALKYL-3-OXOPROPIONATE | RHONE-POULENC AGRICULTURE LIMITED (GB) | 1999-01-12 | — | — | US | disclosed |
| US-5747424-A | HEATING AN AROMATIC DIKETONE WITH A SALT OF HYDROXYLAMINE IN A SOLVENT | RHONE-POULENC AGRICULTURE LTD. (GB) | 1998-05-05 | — | — | US | disclosed |
| US-5656573-A | Herbicidal 4-substituted isoxazoles | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-08-12 | — | — | US | disclosed |
| US-5650533-A | Intermediates to herbicidal 4-substituted isoxazoles | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-07-22 | — | — | US | disclosed |
| US-4356295-A | COORDINATION CATALYSTS | MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) | 1982-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040930-A1 | NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE | MMP9, MMP10, MMP2 | TDP1 2015/4885SMN1; SMN2 2884/4885PKM 3568/4885 |
| US-20190177284-A1 | TETRAZOLYL-CONTAINING CYCLOPROPANECARBOXAMIDES | GAP43, PSEN1, PSEN2 | TDP1 1620/4885SMN1; SMN2 69/4885PKM 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.