Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5926121 | 0.86 | HTR1A (0.46) | HTR1AHTR2AHTR2CDRD3DRD2 | |
| SCHEMBL5926097 | 0.83 | HTR7 (0.56) | HTR1AHTR2ADRD2 | |
| SCHEMBL5926325 | 0.80 | DRD2 (0.48) | HTR1AHTR2ADRD3DRD2 | |
| SCHEMBL5926252 | 0.80 | HTR2A (0.53) | HTR1AHTR2AHTR2CCA1CA2 | |
| SCHEMBL5926141 | 0.79 | KCNH2 (0.53) | HTR1AHTR2ADRD3DRD2 | |
| SCHEMBL27263980 | 0.77 | DRD2 (0.54) | HTR1AHTR2AHTR2CDRD3DRD2 | |
| SCHEMBL6181546 | 0.76 | PKM (0.50) | PIM1HTR1AHTR2AHTR2C | |
| SCHEMBL5926079 | 0.74 | HTR1A (0.54) | HTR1ADRD4 | |
| SCHEMBL5926074 | 0.72 | HTR1A (0.41) | HTR1AHTR2AHTR2CDRD3DRD2 | |
| SCHEMBL5926075 | 0.72 | HTR1A (0.47) | HTR1ADRD3DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060211703-A1 | Substituted alkyl-pyridazinones for the treatment of memory and learning malfunctions | EGIS GYOGYSZERGYAR RT. (HU) | 2006-09-21 | — | — | US | claimed |
| EP-1567159-A1 | SUBSTITUTED ALKYL-PYRIDAZINONES FOR THE TREATMENT OF MEMORY AND LEARNING MALFUNCTIONS | EGIS GYOGYSZERGYAR RT. (HU) | 2005-08-31 | — | — | EP | claimed |
| US-20050043314-A1 | Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same | EGIS GYOGYSZERGYAR RT. (HU) | 2005-02-24 | — | — | US | claimed |
| EP-1430034-B1 | SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2005-02-09 | — | — | EP | claimed |
| EP-1430034-A1 | SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Egis Gyogyszergyar Rt. (HU) | 2004-06-23 | — | — | EP | claimed |
| WO-2004043465-A1 | SUBSTITUTED ALKYL-PYRIDAZINONES FOR THE TREATMENT OF MEMORY AND LEARNING MALFUNCTIONS | EGIS Gyógyszergyár Rt. (HU) | 2004-05-27 | — | — | WO | claimed |
| WO-2003027078-A1 | SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | EGIS Gyógyszergyár Rt. (HU) | 2003-04-03 | — | — | WO | claimed |
| US-20060211703-A1 | Substituted alkyl-pyridazinones for the treatment of memory and learning malfunctions | EGIS GYOGYSZERGYAR RT. (HU) | 2006-09-21 | — | — | US | disclosed |
| EP-1567159-A1 | SUBSTITUTED ALKYL-PYRIDAZINONES FOR THE TREATMENT OF MEMORY AND LEARNING MALFUNCTIONS | EGIS GYOGYSZERGYAR RT. (HU) | 2005-08-31 | — | — | EP | disclosed |
| US-20050043314-A1 | Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same | EGIS GYOGYSZERGYAR RT. (HU) | 2005-02-24 | — | — | US | disclosed |
| EP-1430034-B1 | SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2005-02-09 | — | — | EP | disclosed |
| EP-1430034-A1 | SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Egis Gyogyszergyar Rt. (HU) | 2004-06-23 | — | — | EP | disclosed |
| WO-2004043465-A1 | SUBSTITUTED ALKYL-PYRIDAZINONES FOR THE TREATMENT OF MEMORY AND LEARNING MALFUNCTIONS | EGIS Gyógyszergyár Rt. (HU) | 2004-05-27 | — | — | WO | disclosed |
| WO-2003027078-A1 | SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | EGIS Gyógyszergyár Rt. (HU) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043314-A1 | Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same | CYP2C19, CYP2D6, CYP3A5 | PIM1 2867/4885HTR1A 64/4885HTR2A 78/4885 |
| US-20060211703-A1 | Substituted alkyl-pyridazinones for the treatment of memory and learning malfunctions | CHRM1, CHRM2, CHRM5 | PIM1 3886/4885HTR1A 225/4885HTR2A 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.