Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 7/20 | 0.51 |
| ▸ | DRD4 | P21917 | 5/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5926141 | 0.86 | KCNH2 (0.53) | DRD2KCNH2HTR1AHTR7HTR2A | |
| SCHEMBL5926097 | 0.86 | HTR7 (0.56) | DRD2KCNH2HTR1AHTR7HTR2A | |
| SCHEMBL5926252 | 0.80 | HTR2A (0.53) | DRD2HTR1ADRD4HTR7HTR2A | |
| SCHEMBL27263291 | 0.79 | DRD2 (0.54) | DRD2KCNH2HTR1ADRD4HTR7 | |
| SCHEMBL5926075 | 0.79 | HTR1A (0.47) | DRD2HTR1ADRD4ADRA2AADRA2C | |
| SCHEMBL5926074 | 0.79 | HTR1A (0.41) | DRD2HTR1AHTR2AADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL5926076 | 0.78 | HTR1A (0.41) | DRD2HTR1AHTR7HTR2AADRA1A | |
| Hydrochloric Acid SCHEMBL5926077 | 0.78 | HTR1A (0.47) | DRD2HTR1ADRD4ADRA2AADRA2C | |
| SCHEMBL5926085 | 0.77 | PIM1 (0.47) | DRD2HTR1ADRD4HTR2AHTR2C | |
| SCHEMBL27264122 | 0.76 | DRD4 (0.50) | DRD2KCNH2HTR1ADRD4HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1022565-C | Process for preparing piperazinylalkyl-3(2H)-pyridazinones | CL PHARMA (AT) | 1993-10-27 | — | — | CN | disclosed |
| CN-1043129-A | New piperazinyl alkyl-3 (2H)-pyridazinone, its preparation method and as the application of hypotensive agent | CL PHARMA (AT) | 1990-06-20 | — | — | CN | disclosed |