Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dextrothyroxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 11/20 | 0.58 |
| ▸ | THRA known ✓ | P10827 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | LMNA | P02545 | 6/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.58 |
| ▸ | USP2 | O75604 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | BLM | P54132 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | PPARG | P37231 | 5/20 | 0.58 |
| ▸ | TTR | P02766 | 2/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dextrothyroxine SCHEMBL34102 | 0.84 | THRB (0.76) | THRBMEN1KMT2ALMNAHSD17B10 | |
| Dextrothyroxine SCHEMBL582058 | 0.84 | THRB (0.76) | THRBMEN1KMT2ALMNAHSD17B10 | |
| Dextrothyroxine SCHEMBL1995243 | 0.84 | THRB (0.76) | THRBMEN1KMT2ALMNAHSD17B10 | |
| Dextrothyroxine SCHEMBL5498887 | 0.84 | THRB (0.76) | THRBMEN1KMT2ALMNAHSD17B10 | |
| Dextrothyroxine SCHEMBL4633728 | 0.83 | THRB (0.45) | THRBMEN1KMT2ALMNAHSD17B10 | |
| Dextrothyroxine SCHEMBL2327406 | 0.83 | USP2 (0.76) | THRBMEN1KMT2ALMNAHSD17B10 | |
| Dextrothyroxine SCHEMBL7112166 | 0.83 | USP2 (0.76) | THRBMEN1KMT2ALMNAHSD17B10 | |
| Dextrothyroxine SCHEMBL838270 | 0.83 | USP2 (0.76) | THRBMEN1KMT2ALMNAHSD17B10 | |
| Levothyroxine SCHEMBL4965467 | 0.82 | THRB (0.86) | THRBMEN1KMT2ALMNAHSD17B10 | |
| Levothyroxine SCHEMBL1560691 | 0.82 | THRB (0.86) | THRBMEN1KMT2ALMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060166204-A1 | Parkinson's disease susceptibility haptotype as a tool for genetic screening | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2006-07-27 | — | — | US | disclosed |