Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dextrothyroxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 8/20 | 0.45 |
| ▸ | THRA known ✓ | P10827 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | USP2 | O75604 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dextrothyroxine SCHEMBL5934540 | 0.83 | THRB (0.58) | THRBMEN1KMT2ALMNAUSP2 | |
| Albuterol SCHEMBL4632758 | 0.82 | ADRB2 (0.64) | HSD17B10HIF1AALDH1A1HPGDBLM | |
| Ipratropium SCHEMBL4632130 | 0.78 | MEN1 (0.33) | MEN1KMT2ASMN1; SMN2TSHR | |
| Dextrothyroxine SCHEMBL5498887 | 0.70 | THRB (0.76) | THRBMEN1KMT2ALMNAUSP2 | |
| Dextrothyroxine SCHEMBL1995243 | 0.70 | THRB (0.76) | THRBMEN1KMT2ALMNAUSP2 | |
| Dextrothyroxine SCHEMBL34102 | 0.70 | THRB (0.76) | THRBMEN1KMT2ALMNAUSP2 | |
| Dextrothyroxine SCHEMBL582058 | 0.70 | THRB (0.76) | THRBMEN1KMT2ALMNAUSP2 | |
| Dextrothyroxine SCHEMBL15569465 | 0.69 | THRB (0.91) | THRBMEN1KMT2ALMNAUSP2 | |
| SCHEMBL4632760 | 0.69 | ADRB2 (0.52) | HIF1AADRB2CYP1A2CYP2D6TSHR | |
| Dextrothyroxine SCHEMBL7112166 | 0.69 | USP2 (0.76) | THRBMEN1KMT2ALMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494711-A4 | METHODS FOR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) | ABGENIX INC (US) | 2008-05-28 | — | — | EP | disclosed |
| EP-1494711-A1 | METHODS FOR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) | Abgenix, Inc. (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003080117-A1 | METHODS FOR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) | ABGENIX, INC. (US) | 2003-10-02 | — | — | WO | disclosed |