Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.67 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL12981050 | 1.00 | HCAR2 (0.67) | HCAR2TSHRATMCYP3A4ALDH1A1 | |
| Butoxyethanol SCHEMBL8736361 | 0.92 | TSHR (0.68) | HCAR2TSHRATMCYP3A4ALDH1A1 | |
| Fumaric Acid SCHEMBL12980929 | 0.91 | HCAR2 (0.69) | HCAR2CES2 | |
| Maleic Acid SCHEMBL12980928 | 0.91 | HCAR2 (0.69) | HCAR2CES2 | |
| Maleic Acid SCHEMBL30040841 | 0.90 | HCAR2 (0.56) | HCAR2TSHRATMCYP3A4ALDH1A1 | |
| Maleic Acid SCHEMBL29143549 | 0.90 | HCAR2 (0.56) | HCAR2TSHRATMCYP3A4ALDH1A1 | |
| Maleic Acid SCHEMBL29143547 | 0.90 | HCAR2 (0.56) | HCAR2TSHRATMCYP3A4ALDH1A1 | |
| Crotonic Acid SCHEMBL28102986 | 0.89 | HCAR2 (0.55) | HCAR2TSHRATMCYP3A4ALDH1A1 | |
| SCHEMBL2890706 | 0.87 | HCAR2 (0.79) | HCAR2TSHRATMCYP3A4ALDH1A1 | |
| SCHEMBL2898517 | 0.87 | HCAR2 (0.79) | HCAR2TSHRATMCYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848394-A | Synthesis method and application of maleic acid dihydric alcohol mono-tertiary butyl ether diester | 深圳飞扬兴业科技有限公司 | 2020-10-30 | — | — | CN | disclosed |
| US-20120258249-A1 | LOW/ZERO VOC GLYCOL ETHER-ESTERS AS COALESCENTS FOR AQUEOUS POLYMERIC DISPERSIONS | ADAMSON LINDA A (US) | 2012-10-11 | — | — | US | disclosed |
| US-20060173102-A1 | Synthetic material dispersions | AMI-AGROLINZ MELAMINE INTERNATIONAL GMBH (AT) | 2006-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258249-A1 | LOW/ZERO VOC GLYCOL ETHER-ESTERS AS COALESCENTS FOR AQUEOUS POLYMERIC DISPERSIONS | HDLBP, COG7, COG4 | HCAR2 1290/4885TSHR 4758/4885ATM 4571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.