Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732048 | 0.85 | KMT2A (0.60) | CA2PTGS1PTGS2KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL810 | 0.83 | KMT2A (0.58) | CA2PTGS1PTGS2KMT2AALDH1A1 | |
| SCHEMBL3353838 | 0.83 | CA2 (0.57) | CA2KMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL5444394 | 0.83 | CA2 (0.53) | CA2PTGS1PTGS2KMT2AALDH1A1 | |
| SCHEMBL11123377 | 0.81 | CA2 (0.50) | CA2PTGS1PTGS2KMT2AALDH1A1 | |
| SCHEMBL31518457 | 0.81 | TSHR (0.57) | CA2KMT2AALDH1A1MEN1ALOX15 | |
| SCHEMBL5798626 | 0.79 | KMT2A (0.45) | KMT2AALDH1A1MEN1ALOX15MAPK1 | |
| SCHEMBL11123655 | 0.78 | CA2 (0.51) | CA2PTGS1PTGS2KMT2AALDH1A1 | |
| SCHEMBL27575403 | 0.78 | MEN1 (0.54) | CA2KMT2AALDH1A1MEN1MAPK1 | |
| SCHEMBL7869937 | 0.77 | KMT2A (0.65) | KMT2AALDH1A1MEN1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037349-A | HAVING ANTAGONISTIC PROPERTIES TOWARDS ANGIOTENSIN II CAN BE USED FOR THE TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GMBH (DE) | 2000-03-14 | — | — | US | disclosed |
| US-5798364-A | ANGIOTENSIN II ANTAGONIST, USEFUL FOR TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-08-25 | — | — | US | disclosed |
| EP-0733366-B1 | Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics | DU PONT (US) | 1998-04-01 | — | — | EP | disclosed |
| EP-0324377-B1 | Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids | DU PONT (US) | 1997-04-16 | — | — | EP | disclosed |
| EP-0733366-A2 | Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5532276-A | ANGIOTENSIN II ANTAGONISTS, HYPOTENSIVE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | disclosed |
| US-5520848-A | REACTION OF DIPHENYLAMINE WITH DIISOBUTYLENE AND SULFUR IN THE PRESENCE OF CATALYST | CIBA-GEIGY CORPORATION (US) | 1996-05-28 | — | — | US | disclosed |
| US-5476857-A | Imidazopyridines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-12-19 | — | — | US | disclosed |
| EP-0657454-A1 | Imidazopyridazines being angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1995-06-14 | — | — | EP | disclosed |
| EP-0657452-A1 | Imidazopyridines | MERCK PATENT GmbH (DE) | 1995-06-14 | — | — | EP | disclosed |
| US-5153197-A | Treatment of hypertension with angiotensin II blocking imidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0505893-A1 | Imidazopyridines | MERCK PATENT GmbH (DE) | 1992-09-30 | — | — | EP | disclosed |
| US-5138069-A | Treating hypertension and congestive heart failure | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-08-11 | — | — | US | disclosed |
| US-5128355-A | Hypotensive | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-07-07 | — | — | US | disclosed |
| US-4880804-A | HYPOTENSIVE AGENTS, CONGESTIVE HEART FAILURE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-11-14 | — | — | US | disclosed |
| EP-0324377-A2 | Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-19 | — | — | EP | disclosed |
| WO-1989006233-A1 | ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES AND COMBINATIONS THEREOF WITH DIURETICS AND NSAIDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-13 | — | — | WO | disclosed |
| EP-0253310-A2 | Angiotensin II receptor blocking imidazoles | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-01-20 | — | — | EP | disclosed |
| US-4321081-A | Ortho-(trifluoromethylsulfonamido)benzamides as herbicides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-03-23 | — | — | US | disclosed |
| EP-0038636-A2 | Sulfonamide derivatives, compositions containing them and their production and use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-10-28 | — | — | EP | disclosed |