Sugi Predict

Sugi Predict / Compounds / SCHEMBL594367

SCHEMBL594367

SCHEMBL594367

O=C(O)CC1SC(=O)NC1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 1.00
▸ TSHR P16473 3/20 1.00
▸ HTT P42858 1/20 1.00
▸ GLA P06280 1/20 0.57
▸ HSD17B10 Q99714 1/20 0.57
▸ MAPT P10636 5/20 0.49
▸ CA2 P00918 1/20 0.48
▸ KMT2A Q03164 1/20 0.47
▸ MAOA P21397 2/20 0.44
▸ CISD1 Q9NZ45 2/20 0.44
▸ TDP1 Q9NUW8 3/20 0.43
▸ ESR2 Q92731 1/20 0.43
▸ ADAMTS5 Q9UNA0 1/20 0.43
▸ GAA P10253 1/20 0.43
▸ PPARG P37231 1/20 0.42
▸ MAOB P27338 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7822544 0.82 KDM4E (0.69) KDM4ETSHRHTTGLAHSD17B10
SCHEMBL4328755 0.74 HSD17B10 (1.00) KDM4ETSHRHTTGLAHSD17B10
SCHEMBL1363461 0.73 — —
SCHEMBL264929 0.73 — —
SCHEMBL15427287 0.73 — —
SCHEMBL16924077 0.73 — —
SCHEMBL21393712 0.72 TSHR (0.56) KDM4ETSHRHTTHSD17B10MAPT
SCHEMBL4287734 0.71 KDM4E (0.60) KDM4ETSHRHTTMAPTKMT2A
SCHEMBL4287730 0.71 KDM4E (0.60) KDM4ETSHRHTTMAPTKMT2A
SCHEMBL22623764 0.70 TSHR (0.53) KDM4ETSHRHTTMAPTCA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-9012575-A — — None — — JP disclosed
EP-4573086-A1 METHANOGEN INHIBITORS Agrizeronz Limited Partnership (NZ) 2025-06-25 — — EP disclosed
WO-2024039250-A1 METHANOGEN INHIBITORS PASTORAL GREENHOUSE GAS RESEARCH LIMITED (NZ) 2024-02-22 — — WO disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 — — US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 — — EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 — — EP disclosed
US-20180319812-A1 HETEROCYCLIC COMPOUND ACTION MEDICAL TECHNOLOGIES, LLC 2018-11-08 — — US disclosed
US-10053468-B2 Heterocyclic compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-08-21 — — US disclosed
WO-2018145217-A1 HUMAN ETS-RELATED GENE (ERG) COMPOUNDS AS THERAPEUTICS AND METHODS FOR THEIR USE THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2018-08-16 — — WO disclosed
US-20170050974-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-02-23 — — US disclosed
WO-2010056506-A1 DIACYLGLYCEROL ACLYTRANSFERASE INHIBITORS VIA PHARMACEUTICALS, INC. (US) 2010-05-20 — — WO disclosed
US-20100113782-A1 Diacylglycerol Acyltransferase Inhibitors MADRIGAL PHARMACEUTICALS, INC. 2010-05-06 — — US disclosed
EP-2155687-A1 DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS Via Pharmaceuticals, Inc. (US) 2010-02-24 — — EP disclosed
US-20100035864-A1 Diacylglycerol Acyltransferase Inhibitors MADRIGAL PHARMACEUTICALS, INC. 2010-02-11 — — US disclosed
US-20090170864-A1 Diacylglycerol Acyltransferase Inhibitors MADRIGAL PHARMACEUTICALS, INC. 2009-07-02 — — US disclosed
US-20090105273-A1 Diacylglycerol Acyltransferase Inhibitors MADRIGAL PHARMACEUTICALS, INC. 2009-04-23 — — US disclosed
US-20090099201-A1 Diacylglycerol Acyltransferase Inhibitors VIA PHARMACEUTICALS, INC. 2009-04-16 — — US disclosed
US-20090093497-A1 Diacylglycerol Acyltransferase Inhibitors MADRIGAL PHARMACEUTICALS, INC. 2009-04-09 — — US disclosed
WO-2008141976-A1 DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS VIA PHARMACEUTICALS, INC. (US) 2008-11-27 — — WO disclosed
JP-H0912575-A BENZOXAZINE AND BENZOTHIAZINE DERIVATIVE SANKYO CO LTD 1997-01-14 — — JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10053468-B2 Heterocyclic compound RORC, RORB, RORA KDM4E 925/4885TSHR 1505/4885HTT 3521/4885
US-20170050974-A1 HETEROCYCLIC COMPOUND RORC, RORB, RORA KDM4E 925/4885TSHR 1505/4885HTT 3521/4885
US-20100113782-A1 Diacylglycerol Acyltransferase Inhibitors DGAT2, DGAT1, MOGAT2 KDM4E 3683/4885TSHR 1010/4885HTT 2451/4885
US-20090093497-A1 Diacylglycerol Acyltransferase Inhibitors DGAT2, DGAT1, LCAT KDM4E 2823/4885TSHR 2277/4885HTT 4031/4885
US-20180319812-A1 HETEROCYCLIC COMPOUND RORC, RORB, RORA KDM4E 925/4885TSHR 1505/4885HTT 3521/4885
US-20090170864-A1 Diacylglycerol Acyltransferase Inhibitors DGAT2, DGAT1, LCAT KDM4E 2823/4885TSHR 2277/4885HTT 4031/4885
US-20090099201-A1 Diacylglycerol Acyltransferase Inhibitors DGAT2, DGAT1, LCAT KDM4E 2823/4885TSHR 2277/4885HTT 4031/4885
US-20090105273-A1 Diacylglycerol Acyltransferase Inhibitors DGAT2, DGAT1, LCAT KDM4E 2823/4885TSHR 2277/4885HTT 4031/4885
US-20100035864-A1 Diacylglycerol Acyltransferase Inhibitors DGAT2, DGAT1, LCAT KDM4E 2804/4885TSHR 2286/4885HTT 3918/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.