Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 15/20 | 0.48 |
| ▸ | HTR3A | P46098 | 15/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL546962 | 0.84 | HTR1A (0.67) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL546620 | 0.73 | HTR1A (0.60) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14387771 | 0.68 | HTR1A (0.43) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5335772 | 0.68 | HTR1A (0.43) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5335072 | 0.68 | HTR1A (0.43) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5571143 | 0.68 | SLC6A9 (0.61) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5571148 | 0.68 | SLC6A9 (0.61) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6873426 | 0.67 | HTR1A (0.48) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL547068 | 0.67 | HTR1A (1.00) | HTR1AHTR3ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1203357 | 0.64 | HTR3E (0.56) | HTR3AMAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7138407-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2006-11-21 | — | — | US | disclosed |
| US-20060084662-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2006-04-20 | — | — | US | disclosed |
| EP-1436271-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. Lundbeck A/S (DK) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003029232-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084662-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | TPH1, HTR5A, HTR2C | HTR1A 5/4885HTR3A 9/4885CYP1A2 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.