Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | FABP7 | O15540 | 3/20 | 0.58 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL702762 | 1.00 | ALDH1A1 (0.66) | ALDH1A1GAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL9982540 | 1.00 | ALDH1A1 (0.66) | ALDH1A1GAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL6666657 | 0.95 | FABP7 (0.58) | ALDH1A1GAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL280126 | 0.95 | FABP7 (0.58) | ALDH1A1GAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL10917021 | 0.95 | FABP7 (0.58) | ALDH1A1GAASMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL27765522 | 0.93 | FABP7 (0.57) | ALDH1A1GAASMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL27944947 | 0.93 | FABP7 (0.57) | ALDH1A1GAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL15152701 | 0.88 | FABP7 (0.53) | ALDH1A1GAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL15798022 | 0.88 | FABP7 (0.56) | ALDH1A1GAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL16203189 | 0.88 | FABP7 (0.53) | ALDH1A1GAASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240400587-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS INC (US) | 2024-12-05 | — | — | US | disclosed |
| EP-4430052-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | Nurix Therapeutics, Inc. (US) | 2024-09-18 | — | — | EP | disclosed |
| US-12091426-B2 | Bifunctional degraders of hematopoietic progenitor kinase and therapeutic uses thereof | NURIX THERAPEUTICS, INC. (US) | 2024-09-17 | — | — | US | disclosed |
| US-20240018162-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. | 2024-01-18 | — | — | US | disclosed |
| US-20240018162-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. | 2024-01-18 | — | — | US | disclosed |
| US-20240018162-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. | 2024-01-18 | — | — | US | disclosed |
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |
| US-20220127605-A1 | NUCLEIC ACID CONJUGATE | KYOWA KIRIN CO., LTD. (JP) | 2022-04-28 | — | — | US | disclosed |
| CN-108699558-B | Nucleic acid complexes | 协和麒麟株式会社 | 2021-12-07 | — | — | CN | disclosed |
| US-20090170864-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2009-07-02 | — | — | US | disclosed |
| US-20090105273-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2009-04-23 | — | — | US | disclosed |
| US-20090099201-A1 | Diacylglycerol Acyltransferase Inhibitors | VIA PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| US-20090093497-A1 | Diacylglycerol Acyltransferase Inhibitors | MADRIGAL PHARMACEUTICALS, INC. | 2009-04-09 | — | — | US | disclosed |
| EP-0121383-B1 | BIS-ESTERS OF DICARBOXYLIC ACIDS WITH AMOXICILLIN AND CERTAIN HYDROXYMETHYLPENICILLANATE 1,1-DIOXIDES | PFIZER INC. (US) | 1986-05-07 | — | — | EP | disclosed |
| EP-0083484-B1 | 1,1-ALKANEDIOL DICARBOXYLATE LINKED ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 1986-02-19 | — | — | EP | disclosed |
| EP-0121383-A1 | Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides | PFIZER INC. (US) | 1984-10-10 | — | — | EP | disclosed |
| US-4462934-A | BACTERICIDES FROM PENICILLINS AND PENICILLINASE INHIBITORS | PFIZER INC. (US) | 1984-07-31 | — | — | US | disclosed |
| US-4457924-A | PENICILLINS, OXAPENICILLINS, BETA-LACTAMASE INHIBITORS | PFIZER, INC. (US) | 1984-07-03 | — | — | US | disclosed |
| EP-0083484-A1 | 1,1-Alkanediol dicarboxylate linked antibacterial agents | PFIZER INC. (US) | 1983-07-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127605-A1 | NUCLEIC ACID CONJUGATE | NSUN3, NSUN2, RNASEH1 | ALDH1A1 1924/4885GAA 670/4885SMN1; SMN2 170/4885 |
| US-20090093497-A1 | Diacylglycerol Acyltransferase Inhibitors | DGAT2, DGAT1, LCAT | ALDH1A1 573/4885GAA 200/4885SMN1; SMN2 4066/4885 |
| US-20090170864-A1 | Diacylglycerol Acyltransferase Inhibitors | DGAT2, DGAT1, LCAT | ALDH1A1 573/4885GAA 200/4885SMN1; SMN2 4066/4885 |
| US-20090099201-A1 | Diacylglycerol Acyltransferase Inhibitors | DGAT2, DGAT1, LCAT | ALDH1A1 573/4885GAA 200/4885SMN1; SMN2 4066/4885 |
| US-20090105273-A1 | Diacylglycerol Acyltransferase Inhibitors | DGAT2, DGAT1, LCAT | ALDH1A1 573/4885GAA 200/4885SMN1; SMN2 4066/4885 |
| US-12091426-B2 | Bifunctional degraders of hematopoietic progenitor kinase and therapeutic uses thereof | TTK, HIPK1, CLK1 | ALDH1A1 3226/4885GAA 1648/4885SMN1; SMN2 2215/4885 |
| US-20240400587-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | TTK, HIPK1, CLK1 | ALDH1A1 3226/4885GAA 1648/4885SMN1; SMN2 2215/4885 |
| US-20240018162-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | TTK, HIPK1, CLK1 | ALDH1A1 3226/4885GAA 1648/4885SMN1; SMN2 2215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.