Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 11/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5955633 | 0.87 | CHRNA7 (0.35) | CHRNA7CHRNB2CHRNA4TSHRHTR3E | |
| SCHEMBL5955557 | 0.86 | ALDH1A1 (0.32) | CHRNA7CHRNB2CHRNA4TSHRALDH1A1 | |
| SCHEMBL5955031 | 0.85 | KCNK9 (0.31) | CHRNA7CHRNB2CHRNA4KMT2A | |
| SCHEMBL5955706 | 0.85 | CHRNA7 (0.34) | CHRNA7CHRNB2CHRNA4KMT2AALDH1A1 | |
| SCHEMBL5955010 | 0.83 | KMT2A (0.43) | CHRNA7CHRNB2CHRNA4TSHRKMT2A | |
| SCHEMBL5954814 | 0.82 | ALDH1A1 (0.33) | TSHRALDH1A1 | |
| SCHEMBL5955552 | 0.82 | CHRNA7 (0.35) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL5955699 | 0.81 | CHRNB2 (0.34) | CHRNA7CHRNB2CHRNA4KMT2AALDH1A1 | |
| SCHEMBL5955528 | 0.81 | EPHX2 (0.33) | CHRNA7 | |
| SCHEMBL5954750 | 0.81 | EBP (0.36) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060116395-A1 | 1H-pyrazole and 1h-pyrole-azabicyclic compounds for the treatment of disease | PFIZER INC | 2006-06-01 | — | — | US | claimed |
| US-20040087616-A1 | 1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease | PIOTROWSKI DAVID W (US) | 2004-05-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116395-A1 | 1H-pyrazole and 1h-pyrole-azabicyclic compounds for the treatment of disease | CYP7B1, P2RX7, CYP3A7 | CHRNA7 8/4885CHRNB2 170/4885CHRNA4 85/4885 |
| US-20040087616-A1 | 1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease | CYP1B1, TPMT, CYP7B1 | CHRNA7 2586/4885CHRNB2 3958/4885CHRNA4 3568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.