Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517197 | 0.89 | ALDH1A1 (0.56) | POLBCHRM3CHRM2CHRM1ALDH1A1 | |
| SCHEMBL14582622 | 0.81 | ABCC1 (0.74) | POLBALDH1A1ABCC1SMN1; SMN2CYP2D6 | |
| SCHEMBL669694 | 0.79 | POLB (0.60) | POLBABCC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1221514 | 0.79 | POLB (0.60) | POLBALDH1A1ABCC1SMN1; SMN2KMT2A | |
| SCHEMBL30576775 | 0.79 | POLB (0.60) | POLBABCC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7320026 | 0.79 | POLB (0.79) | POLBALDH1A1SMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL656655 | 0.78 | POLB (0.97) | POLBALDH1A1SMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL3757381 | 0.77 | POLB (0.48) | POLBALDH1A1ABCC1SMN1; SMN2CYP1A2 | |
| SCHEMBL2384053 | 0.77 | KDM4E (0.70) | POLBALDH1A1CYP1A2CYP2D6KMT2A | |
| SCHEMBL30576787 | 0.77 | TAAR1 (0.61) | POLBALDH1A1ABCC1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060211707-A1 | Piperazine-alkyl-ureido derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211707-A1 | Piperazine-alkyl-ureido derivatives | ADRA2C, UTS2R, ADRB2 | POLB 4344/4885CHRM3 221/4885CHRM2 294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.