SCHEMBL5957039

SCHEMBL5957039

Cn1cc(C2=CC(=O)N(c3ccc(Cl)cc3Cl)C2=O)c2ccccc21

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 5/20 0.53
GSK3A P49840 2/20 0.53
CDK4 P11802 2/20 0.53
CCND1 P24385 2/20 0.53
CDK2 P24941 2/20 0.53
KMT2A Q03164 2/20 0.53
MEN1 O00255 1/20 0.53
RGS12 O14924 1/20 0.53
GMNN O75496 1/20 0.53
USP2 O75604 1/20 0.53
CCNB2 O95067 1/20 0.53
LMNA P02545 1/20 0.53
TP53 P04637 1/20 0.53
CYP1A2 P05177 1/20 0.53
CDK1 P06493 1/20 0.53
POLB P06746 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2D6 P10635 1/20 0.53
MAPT P10636 1/20 0.53
CYP2C9 P11712 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29447190 1.00 GSK3B (0.53) GSK3BGSK3ACDK4CCND1CDK2
SCHEMBL30358319 0.83 GSK3B (0.46) GSK3BGSK3ACDK4CCND1CDK2
SCHEMBL22534426 0.81 GSK3B (0.49) GSK3BGSK3ACDK4CCND1CDK2
SCHEMBL27616714 0.75 PTPRC (0.58) GSK3BGSK3ACDK4CCND1CDK2
SCHEMBL8619764 0.73 CAMK2D (0.57) CDK2CCNA2PTPRCPRKCACCNT1
SCHEMBL8920187 0.71 PRKCG (0.59) GSK3BGSK3ACDK4CCND1CDK2
SCHEMBL8923158 0.70 GSK3B (0.47) GSK3BCDK4CCND1CDK2CCNA2
Hydrochloric Acid SCHEMBL8919128 0.70 PRKCG (0.58) GSK3BGSK3ACDK2RPS6KA1PTPRC
Sb-216763 SCHEMBL30251 0.69 GSK3B (1.00) GSK3BGSK3ACDK4CCND1CDK2
Sb-216763 SCHEMBL29361308 0.69 GSK3B (1.00) GSK3BGSK3ACDK4CCND1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1697501-A2 METHOD FOR IN VITRO DIFFERENTIATION OF NEURONAL STEM CELLS OR CELLS DERIVED FROM NEURONAL STEM CELLS AXARON Bioscience AG (DE) 2006-09-06 EP claimed
WO-2005063966-A2 METHOD FOR IN VITRO DIFFERENTIATION OF NEURONAL STEM CELLS OR CELLS DERIVED FROM NEURONAL STEM CELLS AXARON BIOSCIENCE AG (DE) 2005-07-14 WO claimed
WO-2024014497-A1 FIBRIN GEL SHEET FOR CELL TRANSPLANTATION オリヅルセラピューティクス株式会社 2024-01-18 WO disclosed
WO-2023210578-A1 MATURING AGENT HAVING BOTH OF ALK5 INHIBITORY ACTIVITY AND CDK8/19 INHIBITORY ACTIVITY オリヅルセラピューティクス株式会社 2023-11-02 WO disclosed
CN-114207111-A Method for preparing skin-derived pluripotent precursor cells 花王株式会社 2022-03-18 CN disclosed
WO-2021079874-A1 PROLIFERATION INHIBITOR 武田薬品工業株式会社 2021-04-29 WO disclosed
WO-2020209389-A1 METHOD FOR PRODUCING BIOTISSUE-LIKE STRUCTURE 国立大学法人京都大学 2020-10-15 WO disclosed
CN-105039258-B Method and composition by non-neuronal cell reprogramming for neuron cell 北京大学 2018-04-17 CN disclosed