SCHEMBL8920187

SCHEMBL8920187

CN1CCC(n2cc(N3C(=O)C=C(c4cn(C)c5ccccc45)C3=O)c3ccccc32)CC1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCG P05129 11/20 0.59
PRKCB P05771 11/20 0.59
PRKCA P17252 11/20 0.59
PRKCE Q02156 11/20 0.59
PRKCH P24723 10/20 0.59
PRKCD Q05655 10/20 0.59
CAMK2D Q13557 10/20 0.59
CAMK2B Q13554 8/20 0.59
CAMK2G Q13555 8/20 0.59
CAMK2A Q9UQM7 8/20 0.59
PRKCZ Q05513 7/20 0.59
SRC P12931 3/20 0.48
CDK9 P50750 2/20 0.42
CDK2 P24941 2/20 0.42
PIP5K1C O60331 1/20 0.42
RPS6KA5 O75582 1/20 0.42
RPS6KA4 O75676 1/20 0.42
STK16 O75716 1/20 0.42
PAK3 O75914 1/20 0.42
CDK14 O94921 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8919128 0.99 PRKCG (0.58) PRKCGPRKCBPRKCAPRKCEPRKCH
SCHEMBL8920747 0.90 PRKCG (0.61) PRKCGPRKCBPRKCAPRKCEPRKCH
SCHEMBL8921034 0.89 PRKCG (0.62) PRKCGPRKCBPRKCAPRKCEPRKCH
SCHEMBL8920200 0.75 PRKCG (0.43) PRKCGPRKCBPRKCAPRKCEPRKCH
SCHEMBL3146547 0.74 PRKCB (1.00) PRKCGPRKCBPRKCAPRKCEPRKCH
Hydrochloric Acid SCHEMBL8919122 0.74 PRKCB (0.43) PRKCGPRKCBPRKCAPRKCEPRKCH
Hydrochloric Acid SCHEMBL8654403 0.74 PTPRC (0.35) PRKCGPRKCBPRKCAPRKCEPRKCH
Hydrochloric Acid SCHEMBL3155547 0.73 PRKCB (0.98) PRKCGPRKCBPRKCAPRKCEPRKCH
SCHEMBL8619764 0.73 CAMK2D (0.57) PRKCACAMK2DCDK9CDK2PIM1
SCHEMBL30358319 0.72 GSK3B (0.46) PRKCACDK9CDK2GSK3AGSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5672618-A TREATING DIABETIC COMPLICATIONS ELI LILLY AND COMPANY (US) 1997-09-30 US disclosed