⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7278062 | 0.77 | — | — | |
| SCHEMBL7331670 | 0.65 | GABRP (0.31) | — | |
| SCHEMBL2183129 | 0.62 | MAPK1 (0.34) | — | |
| SCHEMBL18689833 | 0.62 | MAPK1 (0.34) | — | |
| SCHEMBL7972172 | 0.61 | — | — | |
| SCHEMBL13125471 | 0.55 | KMT2A (0.31) | — | |
| SCHEMBL3578698 | 0.53 | SLC6A1 (0.32) | — | |
| SCHEMBL24069841 | 0.53 | — | — | |
| SCHEMBL10424405 | 0.52 | MAPK1 (0.31) | — | |
| SCHEMBL5595127 | 0.52 | ARG1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115738-B2 | Hydroxyproline/phosphono oligonucleotide analogues, methods of synthesis and methods of use | ACTIVE MOTIF (US) | 2006-10-03 | — | — | US | disclosed |
| US-6962906-B2 | Oligonucleotide analogues, methods of synthesis and methods of use | ACTIVE MOTIF (US) | 2005-11-08 | — | — | US | disclosed |
| EP-1263773-A4 | OLIGONUCLEOTIDE ANALOGUES, METHODS OF SYNTHESIS AND METHODS OF USE | ACTIVE MOTIF (US) | 2005-08-31 | — | — | EP | disclosed |
| EP-1481085-A2 | OLIGONUCLEOTIDE ANALOGUES AND METHODS OF USE FOR MODULATING GENE EXPRESSION | Active Motif (US) | 2004-12-01 | — | — | EP | disclosed |
| US-20040014644-A1 | Oligonucleotide analogues and methods of use for modulating gene expression | ACTIVE MOTIF. | 2004-01-22 | — | — | US | disclosed |
| WO-2003068798-A2 | OLIGONUCLEOTIDE ANALOGUES AND METHODS OF USE FOR MODULATING GENE EXPRESSION | ACTIVE MOTIF (US) | 2003-08-21 | — | — | WO | disclosed |
| US-20030059789-A1 | Oligonucleotide analogues, methods of synthesis and methods of use | ACTIVE MOTIF | 2003-03-27 | — | — | US | disclosed |
| EP-1263773-A1 | OLIGONUCLEOTIDE ANALOGUES, METHODS OF SYNTHESIS AND METHODS OF USE | Active Motif (US) | 2002-12-11 | — | — | EP | disclosed |
| US-20020155989-A1 | Oligonucleotide analogues, methods of synthesis and methods of use | ACTIVE MOTIF | 2002-10-24 | — | — | US | disclosed |
| WO-2001068673-A1 | OLIGONUCLEOTIDE ANALOGUES, METHODS OF SYNTHESIS AND METHODS OF USE | ACTIVE MOTIF (US) | 2001-09-20 | — | — | WO | disclosed |