Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7614575 | 0.77 | SMN1; SMN2 (0.34) | HPGDKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7753150 | 0.74 | CYP2C19 (0.45) | HPGDKDM4EALDH1A1SMN1; SMN2CYP2C19 | |
| SCHEMBL5969058 | 0.71 | POLB (0.31) | HPGD | |
| SCHEMBL6856849 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL7630764 | 0.69 | CYP2C19 (0.40) | HPGDKDM4EALDH1A1SMN1; SMN2CYP2C19 | |
| Hydrochloric Acid SCHEMBL7644423 | 0.65 | ALDH1A1 (0.41) | HPGDALDH1A1SMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL27844648 | 0.59 | HPGD (0.60) | HPGDKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7246995 | 0.58 | SMN1; SMN2 (0.38) | HPGDKDM4EALDH1A1SMN1; SMN2CYP2C19 | |
| Hydrochloric Acid SCHEMBL7241242 | 0.58 | SMN1; SMN2 (0.38) | HPGDKDM4EALDH1A1SMN1; SMN2CYP2C19 | |
| Hydrochloric Acid SCHEMBL7753199 | 0.58 | CYP2C19 (0.45) | HPGDKDM4EALDH1A1SMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259556-B1 | IMPROVED DERIVATIVES OF SILANE FUNCTIONALIZED OLEFIN INTERPOLYMERS | DOW GLOBAL TECHNOLOGIES INC (US) | 2006-06-07 | — | — | EP | disclosed |
| EP-1054910-B1 | IMPROVED OLEFIN POLYMERIZATION PROCESS | DOW GLOBAL TECHNOLOGIES INC (US) | 2004-09-22 | — | — | EP | disclosed |
| US-6624254-B1 | Uniform distrbution by coupling, hydrolysis, neutralization, condensation, oxidation or hydrosilation; films, sheets, moldings | THE DOW CHEMICAL COMPANY | 2003-09-23 | — | — | US | disclosed |
| EP-1259556-A2 | IMPROVED SILANE FUNCTIONALIZED OLEFIN INTERPOLYMERS AND DERIVATIVES THEREOF | THE DOW CHEMICAL COMPANY (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6258902-B1 | USING A METAL COMPLEX CATALYST AND AN ALKENYL CONTAINING HYDROCARBYLSILANE | THE DOW CHEMICAL COMPANY | 2001-07-10 | — | — | US | disclosed |
| WO-2001009207-A2 | IMPROVED SILANE FUNCTIONALIZED OLEFIN INTERPOLYMERS AND DERIVATIVES THEREOF | THE DOW CHEMICAL COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |
| EP-1054910-A1 | IMPROVED OLEFIN POLYMERIZATION PROCESS | THE DOW CHEMICAL COMPANY (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041289-A1 | IMPROVED OLEFIN POLYMERIZATION PROCESS | THE DOW CHEMICAL COMPANY (US) | 1999-08-19 | — | — | WO | disclosed |