Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CCKAR | P32238 | 1/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7753150 | 0.78 | CYP2C19 (0.45) | ALDH1A1HPGDCYP2C19SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL7630764 | 0.74 | CYP2C19 (0.40) | ALDH1A1HPGDCYP2C19SMN1; SMN2KMT2A | |
| SCHEMBL7644429 | 0.70 | ALDH1A1 (0.40) | ALDH1A1ADORA1HPGDADORA2AADORA3 | |
| Hydrochloric Acid SCHEMBL7752408 | 0.66 | CYP2C19 (0.45) | ALDH1A1HPGDCYP2C19SMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL5968682 | 0.65 | HPGD (0.33) | ALDH1A1ADORA1HPGDCYP2C19SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7753199 | 0.64 | CYP2C19 (0.45) | ALDH1A1HPGDCYP2C19SMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL5854814 | 0.62 | CYP2C19 (0.43) | ALDH1A1HPGDADORA3CYP2C19SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5853853 | 0.62 | CYP2C19 (0.43) | ALDH1A1HPGDADORA3CYP2C19SMN1; SMN2 | |
| SCHEMBL38659461 | 0.62 | ALDH1A1 (0.94) | ALDH1A1ADORA1HPGDADORA2AADORA3 | |
| SCHEMBL17866226 | 0.61 | CYP2C19 (0.45) | ALDH1A1HPGDCYP2C19SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946574-B1 | 3-ARYL SUBSTITUTED INDENYL CONTAINING METAL COMPLEXES AND POLYMERIZATION PROCESS | DOW CHEMICAL CO (US) | 2002-02-13 | — | — | EP | claimed |
| US-5866704-A | 3-aryl substituted indenyl containing metal complexes and polymerization process | THE DOW CHEMICAL COMPANY (US) | 1999-02-02 | — | — | US | claimed |