Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17222372 | 1.00 | — | — | |
| SCHEMBL3666669 | 0.74 | — | — | |
| SCHEMBL28911243 | 0.74 | — | — | |
| SCHEMBL11342595 | 0.74 | TSHR (0.33) | MCL1 | |
| SCHEMBL16814565 | 0.74 | — | — | |
| SCHEMBL28435075 | 0.74 | — | — | |
| SCHEMBL5666365 | 0.74 | MCL1 (0.31) | MCL1 | |
| SCHEMBL906464 | 0.72 | — | — | |
| SCHEMBL320508 | 0.72 | — | — | |
| SCHEMBL1936953 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937173-B2 | Anti-microRNA oligonucleotide molecules | THE ROCKEFELLER UNIVERSITY (US) | 2015-01-20 | — | — | US | disclosed |
| US-20140335605-A1 | Anti-MicroRNA Oligonucleotide Molecules | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-11-13 | — | — | US | disclosed |
| US-8816060-B2 | Anti-microRNA oligonucleotide molecules | ROCKEFELLER UNIVERSITY (US) | 2014-08-26 | — | — | US | disclosed |
| US-20130078715-A1 | Anti-MicroRNA Oligonucleotide Molecules | ROCKEFELLER UNIVERSITY (US) | 2013-03-28 | — | — | US | disclosed |
| US-8318926-B2 | Anti-MicroRNA oligonucleotide molecules | ROCKEFELLER UNIVERSITY (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120115220-A1 | Anti-MicroRNA Oligonucleotide Molecules | ROCKEFELLER UNIVERSITY (US) | 2012-05-10 | — | — | US | disclosed |
| US-8114985-B2 | Anti-MicroRNA oligonucleotide molecules | ROCKEFELLER UNIVERSITY (US) | 2012-02-14 | — | — | US | disclosed |
| US-20110165669-A1 | Anti-MicroRNA Oligonucleotide Molecules | ROCKEFELLER UNIVERSITY (US) | 2011-07-07 | — | — | US | disclosed |
| EP-2327710-A1 | Anti-microRNA oligonucleotide molecules | THE ROCKEFELLER UNIVERSITY (US) | 2011-06-01 | — | — | EP | disclosed |
| US-7943756-B2 | Anti-microRNA oligonucleotide molecules | ROCKEFELLER UNIVERSITY (US) | 2011-05-17 | — | — | US | disclosed |
| US-20100286385-A1 | Anti-MicroRNA Oligonucleotide Molecules | ROCKEFELLER UNIVERSITY (US) | 2010-11-11 | — | — | US | disclosed |
| US-7772389-B2 | Inhibiting ribonucleoprotein particles (miRNPs) activity in a cell | ROCKEFELLER UNIVERSITY (US) | 2010-08-10 | — | — | US | disclosed |
| US-20070287179-A1 | Inhibiting ribonucleoprotein particles (miRNPs) activity in a cell | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-12-13 | — | — | US | disclosed |
| EP-1723162-A2 | ANTI-MICRORNA OLIGONUCLEOTIDE MOLECULES | Rockefeller University (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005079397-A2 | ANTI-MICRORNA OLIGONUCLEOTIDE MOLECULES | ROCKEFELLER UNIVERSITY (US) | 2005-09-01 | — | — | WO | disclosed |
| US-20050182005-A1 | Anti-microRNA oligonucleotide molecules | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-08-18 | — | — | US | disclosed |