Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.42 |
| ▸ | CTSD | P07339 | 2/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 4/20 | 0.41 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439104 | 0.91 | BCHE (0.42) | BACE1CTSDBCHE | |
| SCHEMBL5981756 | 0.89 | BCHE (0.42) | BACE1BCHEF2 | |
| SCHEMBL6527142 | 0.88 | BACE1 (0.43) | BACE1CTSDBACE2BCHEF2 | |
| SCHEMBL6527345 | 0.88 | F2 (0.44) | BACE1CTSDBACE2BCHESPPL2A | |
| SCHEMBL6479685 | 0.88 | BCHE (0.41) | BACE1CTSDBCHEF2 | |
| SCHEMBL6526544 | 0.87 | CTSD (0.50) | BACE1CTSDBCHEF2 | |
| SCHEMBL6529744 | 0.86 | ITGA4 (0.44) | BACE1CTSDBACE2 | |
| SCHEMBL6529408 | 0.82 | F2 (0.41) | BACE1CTSDBACE2BCHEF2 | |
| SCHEMBL6762938 | 0.81 | MEN1 (0.39) | F2 | |
| SCHEMBL6527555 | 0.81 | BACE1 (0.43) | BACE1BACE2BCHEF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040044047-A1 | Alpha and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | G.D. SEARLE & CO. | 2004-03-04 | — | — | US | claimed |
| US-7141609-B2 | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2006-11-28 | — | — | US | disclosed |
| US-20050267171-A1 | Alpha-and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2005-12-01 | — | — | US | disclosed |
| US-20020137942-A1 | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | VAZQUEZ MICHAEL L (US) | 2002-09-26 | — | — | US | disclosed |
| US-6313345-B1 | AIDS TREATMENT | G. D. SEARLE & CO. | 2001-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137942-A1 | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | PRSS1, DNPEP, PREP | BACE1 360/4885CTSD 63/4885BACE2 280/4885 |
| US-20050267171-A1 | Alpha-and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | DNPEP, ASPH, PREP | BACE1 18/4885CTSD 136/4885BACE2 37/4885 |
| US-20040044047-A1 | Alpha and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | DNPEP, PREP, ANPEP | BACE1 30/4885CTSD 130/4885BACE2 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.