Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 6/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5982505 | 0.92 | EPHX2 (0.38) | EPHX2GAABRD4BRD2 | |
| SCHEMBL5983329 | 0.85 | PRCP (0.40) | EPHX2 | |
| SCHEMBL5983912 | 0.72 | KMT2A (0.38) | EPHX2 | |
| SCHEMBL4508954 | 0.72 | BDKRB1 (0.65) | CYP3A4 | |
| SCHEMBL14562790 | 0.56 | CA2 (0.53) | — | |
| SCHEMBL12459449 | 0.56 | GAA (0.53) | GAA | |
| SCHEMBL5686141 | 0.55 | BRD4 (0.60) | HSD11B1EPHX2GAABRD4BRD2 | |
| SCHEMBL5686144 | 0.55 | MMP2 (0.41) | RORCNR1I2 | |
| SCHEMBL5686148 | 0.55 | BRD4 (0.60) | HSD11B1EPHX2GAABRD4BRD2 | |
| SCHEMBL309236 | 0.55 | MEN1 (0.54) | HSD11B1CYP3A4EPHX2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656355-A2 | PIPERAZINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-05-17 | — | — | EP | claimed |
| WO-2005061467-A2 | PIPERAZINE DERIVATIVES AS BRADYKININ ANTAGONISTS | AMGEN INC. (US) | 2005-07-07 | — | — | WO | claimed |