Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL29139836 | 0.91 | ATM (0.42) | POLBATMSLC9A1TSHRMEN1 | |
| Propionamide SCHEMBL4056152 | 0.85 | CYP2C19 (0.39) | ATMMTNR1AMTNR1BSLC9A1MEN1 | |
| SCHEMBL2515078 | 0.85 | ALDH1A1 (0.41) | ATMMTNR1AMTNR1BSLC9A1TSHR | |
| Ammonia Solution, Strong SCHEMBL4028071 | 0.77 | MEN1 (0.41) | MEN1KMT2ANOS1NOS3NOS2 | |
| Ammonia Solution, Strong SCHEMBL3952657 | 0.77 | MEN1 (0.41) | MEN1KMT2ANOS1NOS3NOS2 | |
| Dimethylamine SCHEMBL8811519 | 0.75 | PDPK1 (0.45) | MEN1KMT2ANOS1NOS3NOS2 | |
| Hydrochloric Acid SCHEMBL5228466 | 0.75 | MEN1 (0.40) | MEN1KMT2ABLMPMP22LMNA | |
| SCHEMBL30646221 | 0.72 | KDM4E (0.47) | TSHRMEN1KMT2ANOS1NOS3 | |
| Acetamide SCHEMBL4960612 | 0.71 | HTR2A (0.44) | NOTUMMTNR1AMTNR1BTSHRMEN1 | |
| SCHEMBL11806253 | 0.70 | PNMT (0.47) | LMNACYP3A4CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656355-A2 | PIPERAZINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005061467-A2 | PIPERAZINE DERIVATIVES AS BRADYKININ ANTAGONISTS | AMGEN INC. (US) | 2005-07-07 | — | — | WO | disclosed |