Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetamide SCHEMBL5985486 | 0.85 | POLB (0.39) | CYP2C19HSD17B10ATMMTNR1AMTNR1B | |
| Urea SCHEMBL29139836 | 0.85 | ATM (0.42) | CYP2C19HSD17B10ATMGAAMEN1 | |
| SCHEMBL2515078 | 0.80 | ALDH1A1 (0.41) | KDM1AATMMTNR1AMTNR1BMEN1 | |
| Propionamide SCHEMBL28139767 | 0.74 | CES2 (0.45) | CYP2C19KDM1AHSD17B10GAACES2 | |
| Ammonia Solution, Strong SCHEMBL3952657 | 0.72 | MEN1 (0.41) | KDM1AMEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL4028071 | 0.72 | MEN1 (0.41) | KDM1AMEN1KMT2A | |
| Biphenyl SCHEMBL22558147 | 0.72 | MAPT (0.59) | CYP2C19HSD17B10GAACES2CES1 | |
| Propionamide SCHEMBL17335710 | 0.71 | MTNR1A (0.50) | MTNR1AMTNR1B | |
| Dimethylamine SCHEMBL8811519 | 0.71 | PDPK1 (0.45) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5228466 | 0.70 | MEN1 (0.40) | KDM1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076489-A1 | ARYLSULFONAMIDYL TETRALIN DERIVATIVES AND USES THEREOF | F. Hoffmann-Roche AG (CH) | 2009-07-08 | — | — | EP | claimed |
| WO-2007147762-A1 | ARYLSULFONAMIDYL TETRALIN DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | WO | claimed |