Urea

Urea

SCHEMBL29139836

NC(N)=O.c1ccc2c(c1)C1CCC21

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.42
SLC9A1 P19634 2/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
CYP2C19 P33261 2/20 0.39
POLB P06746 1/20 0.39
CYP3A4 P08684 1/20 0.39
PARP1 P09874 1/20 0.39
MAPT P10636 1/20 0.39
TSHR P16473 1/20 0.39
RECQL P46063 1/20 0.39
BLM P54132 1/20 0.39
PMP22 Q01453 1/20 0.39
HSD17B10 Q99714 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
NOS1 P29475 3/20 0.38
NOS3 P29474 1/20 0.38
NOS2 P35228 1/20 0.38
PIN1 Q13526 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetamide SCHEMBL5985486 0.91 POLB (0.39) ATMSLC9A1MEN1KMT2ACYP2C19
SCHEMBL2515078 0.85 ALDH1A1 (0.41) ATMSLC9A1MEN1KMT2ATSHR
Propionamide SCHEMBL4056152 0.85 CYP2C19 (0.39) ATMSLC9A1MEN1KMT2ACYP2C19
Ammonia Solution, Strong SCHEMBL4028071 0.81 MEN1 (0.41) MEN1KMT2ANOS1NOS3NOS2
Ammonia Solution, Strong SCHEMBL3952657 0.81 MEN1 (0.41) MEN1KMT2ANOS1NOS3NOS2
Hydrochloric Acid SCHEMBL5228466 0.78 MEN1 (0.40) MEN1KMT2ABLMPMP22NOS1
SCHEMBL30646221 0.76 KDM4E (0.47) MEN1KMT2APARP1MAPTTSHR
SCHEMBL11806253 0.74 PNMT (0.47) CYP2C19CYP3A4HSD17B10LMNA
Dimethylamine SCHEMBL8811519 0.74 PDPK1 (0.45) MEN1KMT2ANOS1NOS3NOS2
SCHEMBL27053505 0.74 CA2 (0.38) MEN1KMT2ANOS1NOS3NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110831926-B Tetrahydronaphtyl urea derivatives 持田制药株式会社 2023-11-21 CN disclosed